Figure 4. SDS alters gene expression in the mouse esophagus.

RNA-Seq of whole esophagus homogenates from mice treated with 0.5% SDS in drinking water for 14 days vs. regular drinking water. (A) Heatmap of immune response gene expression. (B) Volcano plot of differentially expressed genes showed changes in barrier- (epithelial) and inflammation-associated (eosinophil, T cell) genes (highlighted yellow). (C) Pathway analysis showing upregulated and downregulated gene expression associated with inflammatory and remodeling pathways. (n=3-5 mice).