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. 2022 Dec 15;16:1010121. doi: 10.3389/fncel.2022.1010121

FIGURE 4.

FIGURE 4

Effects of ChIs on D1- and D2-MSNs glutamate release are mediated through different pathways. (A) Optogenetic activation of ChIs evokes dopamine release in NAc as measured by voltammetry. (i) Representative DA trace and cyclic voltammogram showing characteristic DA waveform. (ii) DA responses evoked from ChI stimulation scatter plot and average ± SEM showing the range of DA currents from 6 slices and 17 recordings. (B) Transformed IEI of D1-MSNs sEPSCs shown as percentiles of cumulative distribution. Data for the control group (ACSF) is reproduced from Figure 2G. IEI is shown before (Pre, white circles) and after (Post, blue circles) ChIs stimulation in control conditions (ACSF) and in presence of antagonists: Sul + SCH (5 uM SCH-23390, D1 receptor antagonist + 1 uM sulpiride, D2 receptor antagonist), Atr (1 uM atropine, mAChR antagonist), Mec (5 uM mecamylamine, nAChR antagonist), and Atr + Mec (atropine + mecamylamine). (C) Same as panel (B) in D2-MSNs. *p < 0.05, ns, no significant difference.