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. 2022 Dec 15;13:1008418. doi: 10.3389/fendo.2022.1008418

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Copyright © 2022 Raimundo, Ferreira, Pobre, Lopes-da-Silva, Brito, dos Santos, Saraiva, dos Santos and Menezes

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Urolithin B induces a massive transcriptomic change in IAPP-expressing cells (A) Heatmap of differently expressed genes of cells expressing ppIAPP with or without 50 µM urolithin B (UroB) and the control expressing the empty vector (left panel). Number of differently expressed genes and distribution in up and downregulation between each comparison (right panel). (B) Functional enrichment analysis obtained from GeneCodis of differently expressed genes between cells expressing ppIAPP with or without 50 µM UroB. The list of genes up and down regulated of the explored pathways is also depicted. E, cells containing the empty vector; I, cells expressing ppIAPP; IU, cells expressing ppIAPP incubated with UroB.