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IAPP expression in yeast leads to the deposition of intracellular aggregates, which in turn interfere with multiple cellular functions such as autophagy, mitochondrial membrane potential homeostasis and redox homeostasis culminating with reduced cell viability and growth (left panel). Treatment of cells with urolithin B protects against IAPP proteotoxicity, preventing the accumulation of toxic intracellular aggregates, improving cellular functions and cell viability (right panel).
