TABLE 3.

Maximum Likelihood Fits of Stratified Linear and Linear-Quadratic Excess Relative Rate (ERR) Models in Dose to LSS Mortality Data of Ozasa et al. (7) for Males and Females Separately, Restricted to Unadjusted Weighted Colon Dose <3 Gy, with Full Follow-up (from 1950–2003) or with Partial Follow-up (1961–2003)^a

		Linear model	Linear-quadratic model
Endpoint	Sex	ERR/Gy (+95% CI)	ERR/Gy (+95% CI)	ERR/Gy2 (+95% CI)	P valueb
Under 3 Gy colon dose, all years of follow-up (1950–2003), adjusted for age at exposure and attained age
All solid cancerc	Males	0.687 (0.434, 0.997)	0.557 (0.049, 1.093)	0.088 (−0.193, 0.422)	0.554
	Females	1.313 (0.996, 1.678)	1.046 (0.556, 1.595)	0.208 (−0.111, 0.555)	0.205
Lungd	Males	1.452 (0.451, 3.330)	1.917 (0.253, 4.787)	−0.291 (−1.281, 0.783)	0.499
	Females	1.022 (0.256, 2.581)	1.159 (0.250, 3.156)	−0.092 (−0.679, 0.461)	0.670
Stomache	Males	0.241 (0.004, 0.625)	−0.125 (−0.469, 0.490)	0.118 (0.003, 0.422)	0.095
	Females	0.993 (0.509, 1.621)	0.765 (0.038, 1.698)	0.150 (−0.291, 0.632)	0.500
All solid excluding lung, stomach, breastc	Males	0.816 (0.443, 1.305)	0.508 (−0.188, 1.273)	0.216 (−0.184, 0.740)	0.300
	Females	1.015 (0.625, 1.463)	0.389 (−0.254, 1.119)	0.468 (0.016, 0.986)	0.042
Leukemiaf	Males	4.758 (2.461, 8.312)	0.394 (−1.263, 3.495)	3.704 (1.430, 7.166)	<0.001
	Females	5.134 (2.713, 8.971)	−0.002 (−1.490, 2.659)	4.280 (2.018, 7.797)	<0.001
All circulatory diseased	Males	0.163 (0.043, 0.324)	0.093 (−0.185, 0.358)	0.039 (−0.070, 0.197)	0.479
	Females	0.273 (0.090, 0.502)	0.312 (0.067, 0.680)	−0.020 (−0.159, 0.095)	0.729
Under 3 Gy colon dose, later years of follow-up (1961–2003), adjusted for age at exposure and attained age
All solid cancerc	Males	0.883 (0.550, 1.307)	0.809 (0.197, 1.499)	0.052 (−0.295, 0.464)	0.777
	Females	1.508 (1.090, 2.001)	1.254 (0.663, 1.952)	0.196 (−0.180, 0.607)	0.310
Lungd	Males	1.397 (0.401, 3.323)	1.693 (−0.027, 4.567)	−0.184 (−1.176, 0.997)	0.676
	Females	1.225 (0.275, 3.297)	1.399 (0.269, 4.061)	−0.110 (−0.870, 0.567)	0.672
Stomache	Males	0.312 (0.000, 0.819)	−0.092 (−0.498, 0.765)	0.076 (0.000, 0.462)	0.138
	Females	1.132 (0.520, 1.971)	0.871 (−0.041, 2.096)	0.171 (−0.396, 0.792)	0.544
All solid excluding lung, stomach, breastc	Males	1.047 (0.543, 1.741)	0.827 (−0.047, 1.894)	0.150 (−0.366, 0.804)	0.569
	Females	1.171 (0.618, 1.825)	0.611 (−0.114, 1.564)	0.399 (−0.114, 0.997)	0.127
Leukemiaf	Males	3.410 (0.523, 7.020)	0.474 (−1.408, 4.325)	2.506 (0.168, 6.210)	0.034
	Females	5.414 (2.459, 11.144)	−0.495 (−2.849, 3.067)	4.933 (1.946, 10.146)	<0.001
All circulatory diseased	Males	0.264 (0.076, 0.517)	0.209 (−0.151, 0.588)	0.035 (−0.118, 0.259)	0.662
	Females	0.310 (0.081, 0.626)	0.401 (0.100, 0.874)	−0.059 (−0.227, 0.083)	0.377

Notes. Profile likelihood confidence intervals (CI) are given for the linear and quadratic coefficients. Models adjusted for age at exposure and attained age^a. Strata defined by city, sex, ground distance category, attained age category, age at exposure category, calendar period, AHS group (and summed/averaged over ground distance).

^aERR models for stomach cancer adjusted for attained age, and for all other endpoints adjusted for age at exposure and attained age.

^bP value of improvement in fit of linear-quadratic model vs linear model.

^cUsing colon dose.

^dUsing lung dose.

^eUsing stomach dose.

^fUsing red bone marrow dose.