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(A) An example PBPK model, utilizing ordinary differential equations (ODEs), which can also be called Physiologically-Based RadioPharmacoKinetic (PBRPK) Model. This model include organs (B) with and (D) without receptors, and includes (C) the kidney which has more sophisticated modeling. Radiopharmaceutical exchange (hot and cold components) between the different compartments is also represented.
