Table 1.
Demographic and clinical characteristics according to the TC/HDL-C ratio quintiles.
| TC/HDL-C | |||||||
|---|---|---|---|---|---|---|---|
| Total | Q1 | Q2 | Q3 | Q4 | Q5 | P for trend | |
| Number | 32,405 | 6,481 | 6,483 | 6,479 | 6,484 | 6,478 | |
| Age, years | 43.9 (0.18) | 42.4 (0.31) | 43.8 (0.30) | 44.1 (0.24) | 44.9 (0.26) | 44.5 (0.24) | <0.001 |
| Gender-female, % | 51.6 (0.27) | 70.6 (0.74) | 62.1 (0.88) | 53.1 (0.75) | 42.2 (0.86) | 30.4 (0.69) | <0.001 |
| Race-white, % | 67.6 (1.19) | 66.6 (1.28) | 67.5 (1.21) | 68.0 (1.38) | 66.5 (1.42) | 69.5 (1.43) | 0.086 |
| Smoking, % | 45.2 (0.57) | 41.5 (0.82) | 41.2 (0.85) | 44.8 (0.87) | 45.0(0.88) | 53.2 (1.00) | <0.001 |
| Body mass index, kg/m2 | 28.4 (0.07) | 25.1 (0.10) | 27.3 (0.11) | 28.8 (0.10) | 30.0 (0.11) | 30.7 (0.12) | <0.001 |
| Systolic blood pressure, mmHg | 121.1 (0.18) | 118.2 (0.30) | 119.4 (0.31) | 120.9(0.26) | 122.3(0.30) | 124.5 (0.33) | <0.001 |
| Diastolic blood pressure, mmHg | 71.1 (0.16) | 68.5 (0.26) | 69.2 (0.22) | 71.0 (0.21) | 72.4 (0.23) | 74.3 (0.28) | <0.001 |
| eGFR, mg/min/1.73 m2 | 88.7 (0.32) | 89.9 (0.53) | 88.7(0.52) | 89.6 (0.56) | 87.4 (0.46) | 87.8 (0.44) | <0.001 |
| Total cholesterol, mg/dl | 198.3 (0.39) | 173.8 (0.56) | 185.7 (0.58) | 194.6 (0.70) | 206.4 (0.61) | 230.5 (0.74) | <0.001 |
| HDL cholesterol, mg/dl | 52.8 (0.16) | 71.4 (0.27) | 58.8 (0.19) | 51.5 (0.19) | 45.3 (0.14) | 37.4 (0.13) | <0.001 |
| TC/HDL-C ratio | 4.1 (0.01) | 2.4 (0.00) | 3.1 (0.00) | 3.7 (0.00) | 4.5 (0.00) | 6.2 (0.02) | <0.001 |
| Comorbidities, % | |||||||
| Hypertension | 33.2 (0.44) | 26.9 (0.70) | 30.2 (0.75) | 34.4 (0.80) | 36.1 (0.83) | 38.2 (0.87) | <0.001 |
| Diabetes | 10.0 (0.23) | 6.8 (0.41) | 8.0 (0.43) | 9.9 (0.42) | 11.5 (0.50) | 13.8 (0.55) | <0.001 |
| Treatment, % | |||||||
| Antihypertensive drugs | 17.6 (0.35) | 14.8 (0.59) | 17.7 (0.65) | 19.5 (0.66) | 19.2 (0.71) | 17.0 (0.59) | 0.002 |
| Hypoglycemic agents, | 5.1 (0.16) | 4.1 (0.34) | 4.5 (0.31) | 5.3 (0.32) | 5.3 (0.34) | 5.9 (0.40) | 0.001 |
| Lipid-lowering drugs | 8.8 (0.25) | 9.1 (0.43) | 10.5 (0.56) | 10.2 (0.51) | 8.3 (0.42) | 5.8 (0.37) | <0.001 |
| Outcomes, % | |||||||
| Cardiovascular disease mortality | 1.0(0.06) | 0.88(0.11) | 0.8 (0.12) | 1.1(0.13) | 1.0 (0.12) | 1.3(0.14) | 0.008 |
| All-cause mortality | 6.1 (0.19) | 5.6 (0.31) | 5.5 (0.29) | 5.7 (0.33) | 6.2 (0.33) | 7.3 (0.35) | <0.001 |
Results are mean (SD) or percentage (number of individuals).
Abbreviations: Q, quintiles; TC/HDL-C, total cholesterol/high-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; Q1, <2.86; Q2, 2.86–3.46; Q3, 3.46–4.12; Q4, 4.12–5.07; Q5,>5.07.