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. 2022 Dec 15;9:1072427. doi: 10.3389/fmed.2022.1072427

TABLE 6.

Count and morphological changes in WBCs, platelets, and RBCs between stable and critical COVID-19 patient groups.

Stable (n = 48) Critical (n = 83)


Frequency Percentage Frequency Percentage P-value
WBC changes
Leucocytosis 2 4.2 2 2.4 0.2867
Leukopenia 2 4.2 2 2.4 0.2867
Neutrophils changes
Neutrophilia 5 10.4 14 16.9 0.1562
Neutropenia 1 2.1 1 1.2 0.3464
Pseudo-Pelger-Huët 11 22.9 22 26.5 0.3242
Bands 11 22.9 23 27.7 0.2732
Long nuclear endoplasm 10 20.8 23 27.7 0.1911
Fetus shaped nucleus 9 18.8 21 25.3 0.195
Macroganular neutrophil cytoplasm 5 10.4 7 8.4 0.3523
Karyorrehxis neutrophils 0 0.0 3 3.6 0.0913
Drumstick nucleus 1 2.1 1 1.2 0.3464
Hypoganular neutrophil cytoplasm 19 39.6 29 34.9 0.2975
Lymphocyte changes
Lymphocytosis 1 2.1 1 1.2 0.3464
Lymphopenia 10 20.8 16 19.3 0.4148
Atypical lymphocytes 39 81.3 66 79.5 0.4054
Granular lymphocyte cytoplasm 3 6.3 2 2.4 0.1345
Basophilic cytoplasm lymphocytes 2 4.2 4 4.8 0.4317
Plasmacytoid lymphocytes 0 0.0 0 0.0
Monocyte changes
Monocytosis 2 4.2 2 2.4 0.2867
Monocytes with vacuoles 24 50.0 48 57.8 0.1927
Platelets changes
Platelets thrombocytosis 10 20.8 7 8.4 0.0209*
Platelets thrombocytopenia 5 10.4 10 12.0 0.3888
RBCs changes
Normocytic RBCs 19 39.6 47 56.6 0.0301*
Normochromic RBCs 11 22.9 33 39.8 0.0246*
Erthrocytopenia 13 27.1 22 26.5 0.4713
Polycythemia 5 10.4 5 6.0 0.1808
Normoblasts 1 2.1 3 3.6 0.3118
Polychromasia 1 2.1 4 4.8 0.2155
Microcytic RBCs 18 37.5 16 19.3 0.0109*
Macrocytic RBCs 1 2.1 1 1.2 0.3464
Hypochromic RBCs 26 54.2 29 34.9 0.0158*
Rouleaux RBCs 9 18.8 14 16.9 0.3925
Anisocytosis 20 41.7 45 54.2 0.0831
Targetoid 18 37.5 29 34.9 0.3842
Stomatocytes 12 25.0 12 14.5 0.0664
Mushroom RBCs 9 18.8 12 14.5 0.2594
Acanthocytes/Spur 7 14.6 17 20.5 0.2002
Ovalocytes 14 29.2 21 25.3 0.315
Dacryocytes 18 37.5 24 28.9 0.1552
Schistocytes 14 29.2 19 22.9 0.2127
Echinocytes/Burr cells 9 18.8 25 30.1 0.0763
Bite cells 12 25.0 16 19.3 0.2207

*p < 0.05, significant results.