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. 2022 Dec 15;9:1072427. doi: 10.3389/fmed.2022.1072427

TABLE 8.

Count and morphological changes in WBCs, platelets, and RBCs between male and female COVID-19 patients.

Male (n = 63) Female (n = 68)


Frequency Percentage Frequency Percentage P-value
WBC changes
Leucocytosis 1 1.6 3 4.4 0.2032
Leukopenia 2 3.2 2 2.9 0.3906
Neutrophils changes
Neutrophilia 13 20.6 6 8.8 0.074
Neutropenia 0 0.0 2 2.9 0.1249
Pseudo-Pelger-Huët 15 23.8 18 26.5 0.4562
Bands 17 27.0 17 25.0 0.3125
Long nuclear endoplasm 17 27.0 16 23.5 0.2271
Fetus shaped nucleus 13 20.6 17 25.0 0.4025
Macroganular neutrophil cytoplasm 6 9.5 6 8.8 0.438
Karyorrehxis neutrophils 1 1.6 2 2.9 0.1903
Drumstick nucleus 0 0.0 2 2.9 0.1249
Hypoganular neutrophil cytoplasm 23 36.5 25 36.8 0.3703
Lymphocyte changes
Lymphocytosis 0 0.0 2 2.9 0.1249
Lymphopenia 16 25.4 10 14.7 0.2869
Atypical lymphocytes 52 82.5 53 77.9 0.4305
Granular lymphocyte cytoplasm 2 3.2 3 4.4 0.2195
Basophilic cytoplasm lymphocytes 3 4.8 3 4.4 0.4405
Plasmacytoid lymphocytes 0 0.0 0 0.0
Monocyte changes
Monocytosis 1 1.6 3 4.4 0.2032
Monocytes with vacuoles 38 60.3 34 50.0 0.1391
Platelets changes
Platelets’ thrombocytosis 7 11.1 10 14.7 0.0794
Platelets’ thrombocytopenia 9 14.3 6 8.8 0.2715
RBCs changes
Normocytic RBCs 33 52.4 33 48.5 0.0903
Normochromic RBCs 28 44.4 16 23.5 0.0093*
Erthrocytopenia 15 23.8 20 29.4 0.347
Polycythemia 6 9.5 4 5.9 0.438
Normoblasts 1 1.6 3 4.4 0.4228
Polychromasia 4 6.3 1 1.5 0.1415
Microcytic RBCs 16 25.4 18 26.5 0.0853
Macrocytic RBCs 2 3.2 0 0.0 0.3627
Hypochromic RBCs 19 30.2 36 52.9 0.0054*
Rouleaux RBCs 13 20.6 10 14.7 0.4025
Anisocytosis 27 42.9 38 55.9 0.45
Targetoid 20 31.7 27 39.7 0.2634
Stomatocytes 9 14.3 15 22.1 0.0767
Mushroom RBCs 11 17.5 10 14.7 0.4305
Acanthocytes/Spur 16 25.4 8 11.8 0.0819
Ovalocytes 21 33.3 14 20.6 0.3199
Dacryocytes 22 34.9 20 29.4 0.3896
Schistocytes 18 28.6 15 22.1 0.4727
Echinocytes/Burr cells 18 28.6 16 23.5 0.1161
Bite cells 13 20.6 15 22.1 0.2927

*p < 0.05, significant results.