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. 2022 Dec 15;4:1052827. doi: 10.3389/frph.2022.1052827

Table 4.

Factors determining the development of EONS among pregnant women with preterm premature rupture of membrane.

Variable Category EONS OR (95% CI)
Yes No
N (%) N (%)
Delivery mode Cesarean 9 (34.6) 17 (65.4) 0.7 (0.3,1.7)
Vaginal 46 (43.0) 61 (57.0) 1.0
Use of Prophylactic Abs Yes 50 (42.4) 68 (57.6) 1.5 (0.4,4.6)
No 5 (33.3) 10 (66.7) 1.00
Use of steroids Yes 14 (58.3) 10 (41.7) 3.5 (1.3,9.3)*
No 41 (30.1) 95 (69.9) 1.0
GA at ROM (week) 28–33 + 6 15 (75.0) 5 (25.0) 5.5 (1.9, 16.8)**
34–36 + 6 40 (35.4) 73 (64.6) 1.0
GA at delivery (week) 28–33 + 6 9 (69.2) 4 (30.8) 3.6 (1. 1, 12.4)
34–36 + 6 46 (38.3) 74 (61.7) 1.0
Latency <72 h 36 (37.9) 59 (62.1) 0.6 (0.3,1.3)
≥72 h 19 (50.0) 19 (50.0) 1.0
Birth weight (gm) Low 32 (57.1) 24 (42.9) 3.13 (1.5,6.4)**
Normal 23 (29.9) 54 (70.1) 1.0
Labor duration (hours) <24 46 (31.3) 101 (68.7) 1.0
≥24 9 (69.2) 4 (30.8) 4.9 (0.1,0.7)**
Chorioamnionitis Yes 7 (58.3) 5 (41.7) 2.9 (0.9,9.7)
No 48 (32.4) 100 (67.6) 1.0

EONS, Early-onset neonatal sepsis; Abs, antibiotics; GA, Gestational age; ROM, rupture of membrane.

*, ** & *** indicate statistically significant difference at p < 0.05, p < 0.01, p < 0.001, respectively.