Table 3.

Mean baseline values, within-group changes after 3–months and the net between-group differences for the change for peak CPET parameters in Allo-HCT and Control groups.

Measure	Allo-HCT	Control	Δ net difference	Group,	Time,	Group x Time,
			(HCT vs. Con)	p	p	p
VO 2 peak, L.min − 1
Baseline	1.8 ± 0.6	2.6 ± 0.7
3–months	1.3 ± 0.4	2.5 ± 0.7
Δ	−0.5 (−0.7, −0.3)***	−0.1 (−0.2, 0.1)	−0.4 (−0.7, −0.1)	<0.001	<0.001	0.006
VO 2 peak, ml.kg −1 .min − 1
Baseline	22.9 ± 8.0	34.8 ± 8.1
3–months	17.5 ± 5.7	33.9 ± 8.0
Δ	−5.4 (−7.7, −3.1)***	−0.9 (−3.6, 1.8)	−4.5 (−8.1, −0.9)	<0.001	0.001	0.015
VO 2 peak, % predicted
Baseline	67 ± 12	104 ± 16
3–months	51 ± 13	101 ± 17
Δ	−16 (−23, −10)***	−3 (−11, 4)	−13 (−23, −3)	<0.001	<0.001	0.012
Peak Power Output, Watts
Baseline	154 ± 62	254 ± 68
3–months	108 ± 44	258 ± 69
Δ	−46 (−59, −32)***	4 (−12, 19)	−50 (−70, −29)	<0.001	<0.001	<0.001
HR peak , % predicted
Baseline	96 ± 8	102 ± 4
3–months	85 ± 11	101 ± 4
Δ	−11 (−15, −6)***	−1 (−6, 5)	−10 (−17, −3)	<0.001	0.002	0.005
Peak RER
Baseline	1.38 ± 0.09	1.33 ± 0.15
3–months	1.31 ± 0.14	1.33 ± 0.07
Δ	−0.07 (−0.13, −0.01)*	0.00 (−0.07, 0.07)	−0.07 (−0.16, 0.02)	0.79	0.13	0.15
VE/VCO2 slope
Baseline	27.8 ± 3.4	26.8 ± 2.9
3–months	32.5 ± 5.5	26.5 ± 4.0
Δ	4.7 (2.3, 7.1)***	−0.3 (−3.0, 2.4)	5.0 (1.4, 8.6)	0.011	0.017	0.008
Peak a–vO 2 diff, %
Baseline	12.0 ± 2.6	14.7 ± 1.7
3–months	10.5 ± 2.7	14.4 ± 1.9
Δ	−1.5 (−2.8, −0.2)*	−0.3 (−1.7, 1.0)	−1.1 (−3.0, 0.7)	<0.001	0.06	0.23

All baseline and 3–month values are unadjusted means ± SDs; all within-group changes are unadjusted mean (95% CI) and expressed as absolute change from baseline. Mean net differences were calculated by subtracting the within–group changes from baseline in the control group from the within–group change from baseline in the allo-HCT group after 3 months. *p < 0.05, ***p < 0.001 vs. baseline. VO₂peak, peak oxygen uptake; HR_peak, peak heart rate; RER, respiratory exchange ratio; peak a–vO₂diff, peak arteriovenous oxygen difference.