Table 5.
Mean baseline values, within-group changes after 3–months and the net between-group differences for the change for body composition and indices of vascular and hematological function in Allo-HCT and Control groups.
| Measure | Allo-HCT | Control | Δ net difference | Group, | Time, | Group x Time, |
|---|---|---|---|---|---|---|
| (HCT vs. Con) | p | p | p | |||
| Weight, kg | ||||||
| Baseline | 80.7 ± 18.2 | 74.3 ± 14.4 | ||||
| 3–months | 76.9 ± 18.1 | 73.6 ± 15.2 | ||||
| Δ | −3.8 (−6.0, −1.5)** | −0.6 (−3.3, 2.1) | −3.2 (−6.7, 0.4) | 0.48 | 0.016 | 0.082 |
| Body mass index, kg.m −2 | ||||||
| Baseline | 27.4 ± 6.2 | 24.6 ± 3.7 | ||||
| 3–months | 26.2 ± 6.3 | 24.4 ± 3.7 | ||||
| Δ | −1.2 (−2.0, −0.5)** | −0.2 (−1.1, 0.7) | −1.0 (−2.2, 0.2) | 0.26 | 0.014 | 0.090 |
| Total LM, kg | ||||||
| Baseline | 51.7 ± 12.9 | 49.5 ± 10.1 | ||||
| 3–months | 48.5 ± 11.9 | 49.5 ± 10.3 | ||||
| Δ | −3.2 (−4.3, −2.0)*** | 0.0 (−1.4, 1.4) | −3.2 (−5.0, −1.3) | 0.001 | 0.88 | 0.001 |
| Total FM, kg | ||||||
| Baseline | 25.9 ± 10.3 | 21.8 ± 8.8 | ||||
| 3–months | 25.3 ± 9.6 | 21.3 ± 8.1 | ||||
| Δ | −0.6 (−2.7, 1.5) | −0.5 (−3.0, 2.0) | −0.1 (−3.4, 3.2) | 0.25 | 0.48 | 0.95 |
| Body fat percentage, % | ||||||
| Baseline | 31.8 ± 8.9 | 29.0 ± 8.8 | ||||
| 3–months | 32.5 ± 8.5 | 28.6 ± 7.5 | ||||
| Δ | 0.7 (−1.4, 2.9) | −0.4 (−3.0, 2.2) | 1.1 (−2.2, 4.5) | 0.28 | 0.84 | 0.50 |
| SBP, mmHg | ||||||
| Baseline | 129 ± 19 | 118 ± 15 | ||||
| 3–months | 127 ± 20 | 118 ± 14 | ||||
| Δ | −2 (−10, 6) | 0 (−10, 10) | −2 (−14, 11) | 0.071 | 0.78 | 0.80 |
| DBP, mmHg | ||||||
| Baseline | 77 ± 15 | 70 ± 11 | ||||
| 3–months | 77 ± 13 | 70 ± 11 | ||||
| Δ | 0 (−5, 5) | −1 (−7, 6) | 1 (−7, 8) | 0.11 | 0.90 | 0.90 |
| Hemoglobin, g.L −1 | ||||||
| Baseline | 114.5 ± 20.0 | 138.9 ± 10.5 | ||||
| 3–months | 107.2 ± 13.3 | 142.3 ± 9.7 | ||||
| Δ | −7.3 (−16.5, 1.9) | 3.4 (−8.6, 15.4) | −10.7 (−25.8, 4.4) | <0.001 | 0.61 | 0.16 |
All baseline and 3–month values are unadjusted means ± SDs; all within-group changes are unadjusted mean (95% CI) and expressed as absolute change from baseline. Mean net differences were calculated by subtracting the within–group changes from baseline in the control group from the within–group change from baseline in the allo–HCT group after 3 months. **p < 0.01, ***p < 0.001 vs. baseline. DBP, diastolic blood pressure; FM, fat mass; LM, lean body mass; SBP, systolic blood pressure.