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. 2022 Dec 15;10:1031872. doi: 10.3389/fcell.2022.1031872

FIGURE 2.

FIGURE 2

C-fos expression of the MSNs in the NAc shell after TLE seizures. (A) Schematic diagram of TLE seizure induction on D1R-cre::Ai14 or D2R-cre::Ai mouse by intra-basolateral amygdala (intra-amygdala) microinjection of KA. (B) Quantification of the percentage of c-fos+ cells in D1R-MSNs or D2R-MSNs (tdTomato+ from Ai14) in the NAc shell. Coloc indicates c-fos+ and tdTomato+ cells; D1/2 indicates tdTomato+ D1R-MSNs or D2R-MSNs. D1 group: n = 16 slices from two mice; D2 group: n = 16 slices from two mice; p > 0.05, Student’s unpaired t test. (C) Quantification of the percentage of tdTomato+ D1R-MSNs or D2R-MSNs in c-fos+ cells in the NAc shell. D1 group: n = 16 slices from two mice; D2 group: n = 16 slices from two mice; *p < 0.05, Student’s unpaired t test. (D) Representative confocal images showing the c-fos expression in the NAc shell of D1R-cre::Ai14 mouse after seizures of the intra-amygdala KA model of TLE. (E) Representative confocal images showing the c-fos expression in the NAc shell of D2R-cre::Ai14 mouse after seizures of the intra-amygdala KA model of TLE.