Table 1.

The binding affinity energy values (docking S-scores) estimated during molecular docking of the fifteen screened NAs against the two SARS-CoV-2 proteins, RdRp and ExoN enzymes (using remdesivir and molnupiravir as the positive control drugs). The fifteen NAs are arranged in a collective descending order, beginning from the top ranked one and ending with the least ranked one

Classification	Compound Name	Docking S-score (kcal/mol)
		RdRp (7BV2)	ExoN (7MC6)
Screened NAs	Riboprine	−7.2	−7.8
	Forodesine	−7.4	−7.6
	Tecadenoson	−7.1	−7.5
	Nelarabine	−7.5	−6.9
	Vidarabine	−7.2	−6.7
	Maribavir	−6.4	−7.4
	Neplanocin A	−7.1	−6.5
	Tubercidin	−6.9	−6.6
	Cladribine	−6.9	−6.6
	Decoyinine	−6.2	−7.1
	Aristeromycin	−6.0	−7.1
	Fludarabine	−6.2	−6.8
	Clofarabine	−6.1	−6.8
	Psicofuranine	−6.1	−6.7
	8-Chloroadenosine	−5.9	−6.9
Reference Drugs	Remdesivir	−6.5	−7.0
	Molnupiravir	−6.3	−7.3