TABLE 4.
Parent-offspring correlation coefficients for the IgG subclass responses to defined and crude P. falciparum antigensa
Antigen and antibody | Urban area
|
Rural area
|
Urban and rural areas
|
|||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Rmo | P | Rfo | P | Rmo | P | Rfo | P | Rmo | P | Rfo | P | |
RESA | ||||||||||||
IgG1 | 0.04 | NS | 0.02 | NS | 0.15 | NS | 0.00 | NS | 0.09 | NS0.00NS | 0.00 | NS |
IgG2 | 0.00 | NS | 0.06 | NS | 0.35 | 0.0014 | 0.20 | 0.0451 | 0.12 | NS | 0.12 | NS |
IgG3 | 0.02 | NS | 0.10 | NS | 0.02 | NS | 0.16 | NS | 0.02 | NS | 0.12 | NS |
IgG4 | 0.00 | NS | 0.13 | NS | 0.20 | NS | 0.40 | 0.0011 | 0.09 | NS | 0.22 | 0.0047 |
IgG | 0.22 | 0.0267 | 0.11 | NS | 0.07 | NS | 0.24 | 0.0169 | 0.16 | 0.0239 | 0.17 | 0.0161 |
MSP-1-Nt | ||||||||||||
IgG1 | 0.20 | 0.0383 | 0.20 | 0.0358 | 0.10 | NS | 0.02 | NS | 0.16 | 0.0299 | 0.10 | NS |
IgG2 | 0.00 | NS | 0.00 | NS | 0.24 | 0.0144 | 0.11 | NS | 0.05 | NS | 0.03 | NS |
IgG3 | 0.27 | 0.0123 | 0.12 | NS | 0.21 | 0.0442 | 0.39 | 0.0007 | 0.24 | 0.0026 | 0.21 | 0.0085 |
IgG4 | 0.22 | 0.0176 | 0.34 | 0.0006 | 0.08 | NS | 0.15 | NS | 0.15 | 0.0396 | 0.24 | 0.0023 |
IgG | 0.24 | 0.0234 | 0.02 | NS | 0.00 | NS | 0.08 | NS | 0.10 | NS | 0.04 | NS |
MSP-2-Nt | ||||||||||||
IgG1 | 0.20 | 0.0454 | 0.30 | 0.0049 | 0.17 | NS | 0.18 | NS | 0.19 | 0.0124 | 0.24 | 0.0018 |
IgG2 | 0.00 | NS | 0.00 | NS | 0.46 | <10–4 | 0.13 | NS | 0.22 | 0.0026 | 0.03 | NS |
IgG3 | 0.20 | 0.0338 | 0.00 | NS | 0.27 | 0.0116 | 0.44 | 0.0001 | 0.21 | 0.0064 | 0.13 | NS |
IgG4 | 0.35 | 0.0021 | 0.35 | 0.0023 | 0.16 | NS | 0.14 | NS | 0.27 | 0.0008 | 0.26 | 0.0014 |
IgG | 0.22 | 0.0311 | 0.00 | NS | 0.15 | NS | 0.05 | NS | 0.19 | 0.0126 | 0.01 | NS |
MSP-2-Ct1 | ||||||||||||
IgG1 | 0.14 | NS | 0.15 | NS | 0.20 | 0.0294 | 0.11 | NS | 0.17 | 0.0144 | 0.12 | NS |
IgG2 | 0.20 | NS | 0.00 | NS | 0.44 | 0.0001 | 0.21 | 0.0418 | 0.31 | 0.0003 | 0.10 | NS |
IgG3 | 0.16 | NS | 0.00 | NS | 0.32 | 0.0025 | 0.37 | 0.0007 | 0.24 | 0.0012 | 0.04 | NS |
IgG4 | 0.33 | 0.0023 | 0.32 | 0.0026 | 0.20 | 0.0328 | 0.13 | NS | 0.27 | 0.0004 | 0.23 | 0.0025 |
IgG | 0.18 | NS | 0.00 | NS | 0.12 | NS | 0.12 | NS | 0.16 | 0.0314 | 0.04 | NS |
MSP-2-Ct2 | ||||||||||||
IgG1 | 0.20 | 0.0307 | 0.25 | 0.0111 | 0.15 | NS | 0.04 | NS | 0.18 | 0.0125 | 0.16 | 0.0190 |
IgG2 | 0.00 | NS | 0.22 | 0.0219 | 0.43 | 0.0001 | 0.25 | 0.0165 | 0.18 | 0.0116 | 0.23 | 0.0023 |
IgG3 | 0.28 | 0.0074 | 0.10 | NS | 0.44 | 0.0001 | 0.39 | 0.0005 | 0.36 | <10–4 | 0.20 | 0.0095 |
IgG4 | 0.45 | 0.0002 | 0.33 | 0.0042 | 0.21 | 0.0271 | 0.22 | 0.0182 | 0.33 | <10–4 | 0.26 | 0.0008 |
IgG | 0.21 | 0.0430 | 0.09 | NS | 0.18 | NS | 0.18 | NS | 0.20 | 0.0079 | 0.14 | 0.0500 |
Extract | ||||||||||||
IgG1 | 0.06 | NS | 0.16 | NS | 0.03 | NS | 0.12 | NS | 0.06 | NS | 0.14 | 0.0400 |
IgG2 | 0.18 | 0.0413 | 0.00 | NS | 0.41 | 0.0003 | 0.22 | 0.0347 | 0.29 | 0.0001 | 0.10 | NS |
IgG3 | 0.24 | 0.0106 | 0.09 | NS | 0.01 | NS | 0.27 | 0.0118 | 0.13 | 0.0498 | 0.13 | NS |
IgG4 | 0.24 | 0.0164 | 0.29 | 0.0055 | 0.08 | NS | 0.03 | NS | 0.15 | 0.0277 | 0.18 | 0.0118 |
IgG | 0.03 | NS | 0.05 | NS | 0.09 | NS | 0.19 | 0.0497 | 0.05 | NS | 0.10 | NS |
Rmo (Rfo) is the Pearson product-moment correlation coefficient between the mother's antibody response (father's antibody response) and the offspring's antibody response.