Fig. 9.

The roles of SIRTs in cancers. SIRTs are involved in a series of malignancies, including BC, LC, liver cancer, GC, PC, colorectal cancer, OC, EC, CC, malignant glioma, and leukemia. SIRTs act as tumor promoters (marked in red color), tumor suppressors (marked in green color), or both suppressor and promoter (marked in blue color). Major events in solid tumor development consist of tumor initiation, tumor proliferation, and tumor metastasis. Between these events, processes including cell proliferation, oxidative stress, apoptosis, angiogenesis, EMT, migration and invasion are promoted or inhibited. Depending on the tumor location, the metastasis site also varies, including lymph nodes, distant organs, liver, adjacent organs, etc. https://biorender.com