Table 1.

Demographic and immunological characteristics of the enrolled children.

		Enrolled children	Group 1	Group 2	p value [Group 1 vs Group 2]
	N	27	15	12
	Age (mean, SD)	8.1 (2.3)	7.8 (2.3)	8.5 (2.3)
	Gender	17F/10M	8F/7M	9F/3M
	Ethnicity	11 Caucasian; 12 Asian; 3 American; 1 African	6 Caucasian; 7 Asian; 1American; 1 African	5 Caucasian; 5 Asian; 2 American
	Positive NPS (pre-vaccine)	3 [11.1%]; mild symptoms	3 [11.1%]; mild symptoms	0%
Anti-N IgG	T0	0.86 [0.24-3.7]	1.99 [0.75-4.8]	0.24 [0.1-0.8]	0.002
	T1	0.45 [0.22-1.3]	0.3 [0.11-1.13]	0.22 [0.1-0.7]	0.02
Anti-TrimericS IgG BAU/ml	T0	63.1 [6-929]	255 [163-1430]	5.430 [4.8-31.3]	<0.0001
	T1	8380 [5120-11800]	11200 [8120-26400]	5765 [2405-8388]	0.001
Neutralization Wuhan IC50	T0	16 [8-160]	160 [64-256]	8 [8-8]	<0.0001
	T1	1024 [1024-1024]	1024 [1024-1024]	1024 [640-1024]	0.047
Inhibitory activity Omicron	T0	0.1 [0.1-10]	10 [0.1-10]	0.1 [0.1-0.1]	0.0065
	T1	30 [10-90]	30 [30-90]	10 [0.1-03]	0.01
Spike-specific memory B cells [%]	T0	0.017 [0-0.08]	0.06 [0.03-0.12]	0 [0-0]	<0.0001
	T1	0.1 [0.04-0.3]	0.23 [0.09-0.84]	0.038 [0.01-0.1]	0.0002
T cells specific for Wuhan Spike [SFC/10^6]	T0	133 [11.5-338]	137 [36-330.5]	47 [0-677]	ns
	T1	563 [154-1985]	588 [358-2409]	174 [133-1207]	ns
T cells specific for Omicron Spike [SFC/10^6]	T0	7 [0-43.5]	20 [0-68.5]	0 [0-17]	ns
	T1	27 [5-140]	91.5 [17.2-264.5]	17 [3-27]	0.0479
T cells specific for Wuhan reference Spike [SFC/10^6]	T0	0 [0-36.5]	6.5 [0-83.2]	0 [0-3]	ns
	T1	40 [3.5-150]	131.5 [31.7-351]	20 [0-40]	0.0108

ns means not significant.