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. 2022 Nov 28;25(1):34. doi: 10.3892/etm.2022.11733

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Silencing of ALOX5 promotes cell cycle progression and suppresses cell apoptosis in HG-induced SV40 MES-13 cells. (A) The HG-induced SV40 MES-13 cells were transfected with si-ALOX5 or si-control, and the cell cycle distribution of each group was assessed by flow cytometric analysis. The green region indicates the G1 phase; the yellow region indicates the S phase; the blue region indicates the G2 phase. (B) The cell apoptosis rate of each group was evaluated by flow cytometric analysis. (C) The expression of apoptosis-related proteins, including Bcl-2, Bax and cleaved caspase-3, were assessed using western blotting. ^***P<0.001 vs. NG; ^##P<0.01 and ^###P<0.001 vs. HG + si-control. ALOX5, 5-lipoxygenase; HG, high glucose; si-, siRNA; NG, normal glucose.