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Silencing of ALOX5 weakens the NF-κB signaling pathway in HG-induced SV40 MES-13 cells. The HG-induced SV40 MES-13 cells were transfected with si-ALOX5 or si-control, and the protein expression of p-IκBα, IκBα, p-p65, and p65 was measured using western blotting. ***P<0.001 vs. NG; ###P<0.001 vs. HG + si-control. ALOX5, 5-lipoxygenase; HG, high glucose; si-, siRNA; p-, phosphorylated; IκBα, NF-κB inhibitor α; NG, normal glucose.
