Figure 1.

Age- and sex-adjusted hazard ratios across 17 categories of LDL-C for CVD mortality. (A) LDL-C categories (mg/dL: <50, 50–59 to 190–199 by 10, ≥200, 100–109 as reference). The midpoint was used as a representative value of each LDL-C category, except both ends (40 and 213) for which the median was used. (B) Restricted cubic splines of LDL-C with five knots (5th, 27.5th, 50th, 72.5th and 95th percentiles) and 125 mg/dL as a reference were used. Hazard ratios and 95% CIs were calculated using Cox proportional-hazards models with adjustment for sex (for all participants only) and age at baseline as a continuous variable. CVD, cardiovascular disease; LDL-C, low density lipoprotein cholesterol. To convert LDL-C from mg/dL to mmol/L, multiply by 0.02586