Table 1.
DALYS (95% UI) | Deaths (95% UI) | |||||||||
---|---|---|---|---|---|---|---|---|---|---|
1990 | 2019 | 1990 | 2019 | |||||||
Number | Age-standardized rate | Number | Age-standardized rate | EAPC (95% CI) | Number | Age-standardized rate | Number | Age-standardized rate | EAPC (95% CI) | |
Global | 8,610,219 (4,279,938–15,888,866) | 242.98 (122.16–463.63) | 15,747,938 (8,515,094–28,617,801) | 198.42 (108.16–360.32) | −0.68% (−0.85%– −0.5%)* | 452,167 (216,170–847,600) | 14.98 (7.39–27.35) | 831,502 (427,076–1,470,299) | 11.1 (5.66–19.51) | −1% (−1.13– −0.86%)* |
Gender | ||||||||||
Male | 3,822,568 (1,699,535–7,686,610) | 242.64 (108.58–473.02) | 7,393,039 (,3670,580–14,081,417) | 205.53 (102.86–388.82) | −0.55% (−0.79– −0.31%)* | 181,108 (76,631–364,253) | 14.5 (6.26–28.92) | 357,143 (169,396–680,789) | 11.3 (5.49–21.31) | −0.82% (−0.91– −0.73%)* |
Female | 4,787,651 (2,562,970–8,529,430) | 240.15 (130.11–423.46) | 8,354,899 (4,779,724–14,197,377) | 190.92 (109.35–324.61) | −0.77% (−0.95– −0.59%)* | 271,060 (140,967–478,371) | 15.02 (7.84–26.34) | 474,359 (259,445–776,467) | 10.79 (5.9–17.66) | −1.1% (−1.26– −0.94%)* |
Age group | ||||||||||
15–49 year | 845,106 (313,012–2,003,122) | 31.16 (11.54–73.86) | 1,511,729 (630,966–3,323,968) | 38.42 (16.03–84.47) | 0.74% (0.58–0.91%)* | 14,503 (5,139–36,494) | 0.53 (0.19–1.35) | 22,839 (9,123–54,543) | 0.58 (0.23–1.39) | 0.31% (0.1–0.51%)* |
50–69 year | 3,210,061 (1,414,273–6,267,917) | 470.59 (207.33–918.86) | 5,498,659 (2,737,963–10,224,113) | 398.76 (198.55–741.44) | −0.55% (−0.78– −0.31%)* | 97,952 (42,020–199,610) | 14.36 (6.16–29.26) | 149,142 (71,519–289,033) | 10.82 (5.19–20.96) | −0.95% (−1.15– −0.74%)* |
70+ year | 4,555,052 (2,241,196–8,240,767) | 2,260.05 (1,112–4,088.77) | 8,737,550 (4,797,272–14,984,349) | 1,884.41 (1,034.62–3,231.65) | −0.61% (−0.68– −0.54%)* | 339,713 (166,291–621,622) | 168.55 (82.51–308.43) | 659,522 (346,571–1,154,813) | 142.24 (74.74–249.06) | −0.56% (−0.63– −0.49%)* |
SDI region | ||||||||||
High SDI | 2,484,828 (1,187,789–4,619,856) | 237.33 (113.59–438.86) | 2,822,705 (1,550,644–4,956,505) | 148.99 (82.29–265.06) | −1.54% (−1.71%– −1.38%)* | 153,029 (70,019–284,466) | 14.81 (6.78–27.7) | 160,418 (81,741–278,205) | 7.11 (3.64–12.33) | −2.47% (−2.61– −2.33%)* |
High-middle SDI | 2,590,024 (1,302,702–4,906,984) | 272.46 (136.82–524.66) | 4,113,288 (2,253,717–7,387,863) | 205.66 (113.48–369.84) | −0.93% (−1.17– −0.68%)* | 142,712 (69,654–269,860) | 17.58 (8.71–32.39) | 245,873 (127,841–424,379) | 12.72 (6.59–21.93) | −1.11% (−1.28– −0.95%)* |
Middle SDI | 1,971,547 (991,603–3,639,029) | 223.18 (113.37–428.86) | 5,116,312 (2,649,084–9,308,525) | 226.37 (118.77–412.39) | 0.06% (−0.06–0.19%) | 89,431 (43,754–170,994) | 13.03 (6.42–24.22) | 253,036 (130,439–465,025) | 13.08 (6.71–23.45) | 0.05% (−0.14–0.23%) |
Low-middle SDI | 1,163,948 (597,284–2,201,058) | 225.21 (118.72–408.17) | 2,812,297 (150,9475–5,217,108) | 227.48 (126.31–413.94) | 0.03% (−0.31–0.37%) | 50,340 (26,040–94,977) | 12.77 (6.78–22.98) | 134,393 (72,961–243,267) | 12.87 (7.02–22.47) | 0.05% (−0.25–0.35%) |
Low SDI | 392,832 (189,723–777,225) | 189.88 (95.67–367) | 868,376 (433,708–1,685,312) | 186.9 (96.32–352.25) | −0.03% (−0.13–0.07%) | 16,300 (8,006–32,465) | 10.33 (5.16–19.56) | 37,085 (18,670–71,177) | 10.07 (5.26–18.76) | −0.04% (−0.18–0.09%) |
Type of Cause | ||||||||||
Breast cancer | 109,946 (51,946–202,204) | 2.76 (1.3–4.99) | 197,797 (97,517–345,136) | 2.41 (1.18–4.18) | −0.44% (−0.65– −0.24%)* | 4,412 (2,006–7,693) | 0.12 (0.06–0.22) | 8,475 (4,078–14,305) | 0.11 (0.05–0.18) | −0.49% (−0.62– −0.35%)* |
Colon and rectum cancer | 497,973 (119,163–983,803) | 13.58 (3.32–26.89) | 1,004,854 (262,148–1,943,581) | 12.57 (3.36–24.19) | −0.26% (−0.41– −0.1%)* | 26,931 (6,792–52,678) | 0.82 (0.22–1.59) | 58,657 (16,866–11,2146) | 0.77 (0.22–1.47) | −0.22% (−0.38– −0.05%)* |
Diabetes mellitus | 1,719,775 (782,033–3,071,194) | 45 (21.34–79.47) | 4,549,207 (2,188,516–7,969,495) | 55.92 (27.16–97.6) | 0.76% (0.7–0.82%)* | 49,781 (24,517–84,624) | 1.48 (0.75–2.46) | 125,195 (62,096–20,8347) | 1.62 (0.81–2.68) | 0.33% (0.21–0.44%)* |
Ischemic heart disease | 4,843,158 (1,512,330–1,1108,881) | 138.09 (45.07–310.37) | 7,586,666 (2,613,511–16,747,205) | 96.36 (33.45–210.82) | −1.21% (−1.41– −1%)* | 283,397 (93,687–616,215) | 9.46 (3.25–19.81) | 486,780 (175,734–1003,279) | 6.52 (2.36–13.31) | −1.34% (−1.48– −1.2%)* |
Stroke | 1,439,367 (240,415–3,930,837) | 43.55 (7.56–117.17) | 2,409,414 (432,866–6,377,618) | 31.16 (5.69–82.02) | −1.12% (−1.29– −0.95%)* | 87,646 (15,903–231,493) | 3.09 (0.55–8.09) | 152,395 (30,078–391,946) | 2.08 (0.41–5.33) | −1.25% (−1.38– −1.13%)* |
Southeast Asia, east Asia, and Oceania | ||||||||||
Southeast Asia | 357,415 (159,275–728,328) | 159.12 (72.36–317.48) | 1,071,093 (510,119–2,015,086) | 192.59 (93.69–364.18) | 0.67% (0.51–0.83%)* | 16,079 (7,272–32,907) | 8.85 (4.02–17.89) | 48,523 (23,525–94,810) | 10.22 (4.98–19.55) | 0.53% (0.37–0.69%)* |
East Asia | 989,257 (477,923–2,011,827) | 146.7 (70.85–286.06) | 2,608,318 (1,248,949–5,019,410) | 145.71 (70.1–277.73) | −0.06% (−0.5–0.39%) | 47,950 (22,371–95,799) | 9.45 (4.29–18.01) | 155,135 (70,839–301,472) | 10.08 (4.61–19.18) | 0.2% (−0.27–0.67%) |
Oceania | 10,606 (4,965–20,904) | 384.63 (190.97–734.57) | 34,526 (16,010–66,541) | 512.13 (255.75–933.3) | 0.96% (0.88–1.05%)* | 380 (184–731) | 18.89 (9.54–34.71) | 1,211 (584–2,273) | 24.26 (12.32–43.74) | 0.86% (0.76–0.96%)* |
Sub-Saharan Africa | ||||||||||
Western Sub-Saharan Africa | 114,599 (51,109–231,177) | 149.11 (69.02–295.01) | 270,371 (128,726–524,869) | 164.95 (79.63–311.33) | 0.36% (0.31–0.41%)* | 5,284 (2,411–10,757) | 8.5 (3.96–16.91) | 12,071 (5,835–23,512) | 9.19 (4.55–17.49) | 0.27% (0.23–0.3%)* |
Central Sub-Saharan Africa | 42,818 (20,060–87,679) | 215.7 (103.67–423.1) | 105,469 (49,307–214,533) | 224.35 (110.39–447.23) | 0.16% (0.05–0.26%)* | 1,612 (761–3,246) | 11.22 (5.41–21.74) | 4,068 (1,956–8,143) | 11.68 (5.83–22.1) | 0.15% (0.06–0.23%)* |
Southern Sub-Saharan Africa | 64,099 (33,309–112,902) | 238.99 (126.42–414.92) | 156,452 (83,248–273,310) | 300.35 (161.09–516.88) | 0.78% (0.16–1.4%)* | 2,627 (1,405–4,557) | 11.69 (6.3–20.08) | 6,916 (3,853–11,495) | 15.82 (8.72–26.06) | 1.06% (0.44–1.67%)* |
Eastern Sub-Saharan Africa | 40,573 (17,674–94,236) | 61.39 (27.43–136.89) | 86,497 (38,402–197,538) | 61.33 (27.94–132.71) | −0.01% (−0.14–0.13%) | 1,681 (754–3,806) | 3.28 (1.46–7.37) | 3,807 (1,721–8,300) | 3.42 (1.59–6.95) | 0.15% (0.05–0.25%)* |
South Asia | 1,038,360 (476,678–2,138,271) | 219.98 (107.45–423.96) | 2,521,754 (1,222,855–4,926,863) | 205.79 (103.23–389.87) | −0.16% (−0.53–0.23%) | 43,636 (20,702–86,504) | 12.56 (5.97–23.69) | 125,246 (62,820–234,488) | 12.28 (6.2–22.24) | 0.04% (−0.81–0.88%) |
Latin America and Caribbean | ||||||||||
Tropical Latin America | 55,9370 (321,217–893,191) | 636.73 (363.81–985) | 1,060,731 (674,410–1,545,535) | 442.21 (282.83–640.49) | −1.23% (−1.45– −1.02%)* | 22,780 (12,759–34,992) | 32.31 (18.71–49.08) | 46,039 (30,257–65,105) | 20.19 (13.29–28.35) | −1.58% (−1.81– −1.35%)* |
Caribbean | 114,827 (61,351–196,442) | 457.9 (245.5–773.86) | 226,644 (127,559–375,365) | 438.9 (247.01–726.29) | −0.1% (−0.44–0.25%) | 5,731 (2,957–9,505) | 25.08 (13.05–41.36) | 10,732 (6,046–17,156) | 20.67 (11.63–33.01) | −0.62% (−1– −0.24%)* |
Andean Latin America | 20241 (8070–44270) | 106.53 (43.75–231.41) | 63455 (29372–122469) | 116.04 (53.66–223.2) | 0.3% (0%−0.61%)* | 1040 (394–2343) | 6.2 (2.35–13.79) | 3184 (1437–6338) | 6.05 (2.74–11.99) | −0.01% (−0.41%−0.38%) |
Central Latin America | 136,849 (59,972–272,590) | 169.6 (76.09–334.71) | 382,135 (17,5588–746,326) | 164.37 (75.53–318.25) | −0.06% (−0.43–0.31%) | 5,529 (2,474–11,531) | 8.14 (3.57–16.78) | 16,992 (7,920–34,479) | 7.67 (3.58–15.55) | −0.16% (−0.62–0.3%) |
North Africa and Middle East | 1,168,562 (593,062–2,079,278) | 743.17 (394.66–1,269.24) | 2,774,669 (1,553,821–4,605,278) | 671.93 (389.1–1,089.52) | −0.34% (−0.5– −0.18%)* | 52,083 (2,7534–88,413) | 41.03 (22.62–67.17) | 118,938 (68,023–192,144) | 34.84 (20.38–54.4) | −0.55% (−0.79– −0.31%)* |
Central Europe, eastern Europe, and central Asia | ||||||||||
Central Europe | 389,819 (184,910–767,446) | 288.02 (138.8–576.61) | 449,406 (242,986–819,972) | 204.02 (109.92–378.59) | −1.18% (−1.36– −1%)* | 22,968 (1,0648–45,315) | 19.11 (8.98–36.4) | 29,661 (15,213–53,902) | 13.16 (6.77–23.82) | −1.28% (−1.5– −1.07%)* |
Central Asia | 100,565 (44,213–204,356) | 242.22 (107.49–489.48) | 183,621 (83,640–372,325) | 316.56 (147.06–622.36) | 0.98% (0.71–1.24%)* | 6,245 (2,746–12,505) | 16.58 (7.17–32.55) | 10,182 (4,528–20,044) | 21.48 (9.76–41.4) | 0.94% (0.54–1.35%)* |
Eastern Europe | 656,387 (286,290–1,363,223) | 262.67 (116.86–546.75) | 827,311 (384,730–1,655,166) | 232.62 (108.15–473.82) | −0.34% (−0.74–0.07%) | 42,901 (1,8957–85,790) | 19.35 (8.6–37.47) | 61,101 (28,476–113,768) | 17.34 (8.09–32.3) | −0.23% (−0.58–0.13%) |
High-income regions | ||||||||||
High-income North America | 821,850 (361,036–1,628,151) | 229.31 (101.56–454.13) | 815,447 (401,024–1,522,883) | 130.43 (64.35–247.58) | −1.9% (−2.11– −1.69%)* | 49,867 (20,682–97,011) | 13.47 (5.59–26.21) | 42,882 (18,824–86,186) | 6.03 (2.69–12.16) | −2.69% (−2.86– −2.51%)* |
High-income Asia Pacific | 306,541 (143,702–592,570) | 164.55 (77.56–316.06) | 433,585 (223,989–756,074) | 90.47 (44.97–163.23) | −2.06% (−2.19– −1.93%)* | 16,653 (7,342–31,518) | 10.12 (4.43–19.16) | 26,345 (12,585–46,285) | 4.27 (2.09–7.5) | −2.97% (−3.14– −2.8%)* |
Australasia | 64,131 (29,997–122,576) | 280.32 (130.39–533.95) | 85,146 (49,256–136,839) | 166.58 (95.23–272.4) | −1.75% (−1.95– −1.55%)* | 3,948 (1,781–7,278) | 18.23 (8.18–33.36) | 5,318 (2,854–8,609) | 9.25 (5.02–15) | −2.29% (−2.69– −1.89%)* |
Western Europe | 1,582,352 (775,460–2,881,469) | 268.41 (133.23–488.25) | 1,538,622 (859,919–2,565,771) | 158.08 (88.48–268.59) | −1.73% (−2.06– −1.39%)* | 101,470 (48,163–181,774) | 17.25 (8.23–30.99) | 100,394 (52,964–163,813) | 8.61 (4.54–14.23) | −2.27% (−2.42– −2.12%)* |
Southern Latin America | 30,997 (13,366–71,216) | 71.25 (30.63–164.57) | 52,686 (27,393–101,807) | 62.78 (32.67–121.29) | −0.37% (−0.84%−0.09%) | 1,703 (689–4,055) | 4.33 (1.7–10.35) | 2,760 (1,379–5,396) | 3.2 (1.6–6.27) | −0.93% (−1.36– −0.5%)* |
represents statistically significant.