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. 2022 Dec 29;14:146. doi: 10.1186/s13073-022-01151-6

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Neutralizing antibody levels in vaccinated individuals with or without booster vaccination. a–c Box-violin plots showing the median neutralizing antibody titers against the SARS-CoV-2 D614G, Delta, and Omicron subvariants in vaccinated, unboosted individuals approximately 1 month (M1) (a), 3 months (M3) (b), and 7 months (M7) (c) after the second dose vaccination of BBIBP-CoV (left), along with cumulative distribution function plots of titers against D614G, Delta, and Omicron subvariant (right), showing the proportion of samples at or above a given titer. d, e Box-violin plots of titers against the SARS-CoV-2 D614G, Delta, and Omicron subvariants in BBIBP-CoV booster vaccinated (d) and ZF2001 booster vaccinated (e) individuals (left), along with cumulative distribution function plots of titers against D614G, Delta, and Omicron subvariant (right), showing the proportion of samples at or above a given titer. For the box-violin plots, the median is represented by the thick black line inside the box. The geomatic mean titers (GMTs) are shown above each column. The fold change in GMT is displayed in a–e. The horizontal dotted line represents the limit of detection of 30. A two-tailed Friedman test with a false discovery rate for multiple comparisons was performed to compare Delta and Omicron subvariants to D614G in a–e. p values are represented as *p < 0.05, ***p < 0.001, and ****p < 0.0001. No asterisk indicates no statistical significance.