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. 2022 Apr 4;67(1):36–49. doi: 10.1165/rcmb.2021-0428OC

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Figure 3. — Effect of Aurora A inhibition in YAP inactivation is independent of effects on mitosis. (A) Western blot and quantification showing the decrease in phosphorylated AURKA on T288 1 hour after changing to serum-free media and MK-5108 treatment. ***P < 0.001. (B) Average percentage of cells with positive nuclear YAP localization during a time course of MK-5108 treatment, after overnight prestarvation of the cells in serum-free medium. Data represent mean ± SD. (C) Average cell numbers of three individual wells after immunostaining in 96-well plates, after MK-5108 treatment in HLFs, with or without prestarvation for 16 hours. Data represent mean ± SD. (D) Average percentage of cells with YAP nuclear localization correlation coefficient greater than 0.7, in DMSO- or MK-5108–treated HLFs, with or without prestarvation for 16 hours. Data represent mean ± SD.