Table 1. Available Information, from Safety Data Sheet, on the Toxicity of ChCl and HBD1–6a.
| Component | CLP classificationb | Acute toxicity to rat (oral LD50c) | Toxicity to fish (LC50d) |
|---|---|---|---|
| ChCl (HBA) | Not a hazardous substance | LD50 = 3.40 g/kge | No data available |
| Gly (HBD1) | Not a hazardous substance | LD50 = 27.2 g/kg | LC50 = 54000 mg/L |
| Rainbow trout (Oncorhynchus mykiss) | |||
| Static test, 96 h | |||
| EG (HBD2) | Acute toxicity, oral (category 4) Specific target organ toxicity, repeated exposure, oral (category 2), kidney | No data available | LC50 = 72860 mg/L |
| Fathead minnow (Pimephales promelas) | |||
| Static test, 96 h | |||
| U (HBD3) | Not a hazardous substance | LD50 = 8.47 g/kg | No data available |
| Glu (HBD4) | Not a hazardous substance | LD50 = 25.8 g/kg | No data available |
| MA (HBD5) | Serious eye damage (category 1) | LD50 = 3.25 g/kg | LC50 = 95.4 mg/L |
| Japanese rice fish (Oryzias latipes) | |||
| Flow-through test, 96 h | |||
| LA (HBD6) | Skin irritation (category 2) | LD50 = 3.54 g/kg | LC50 = 130 mg/L, |
| Serious eye damage (category 1) | Rainbow trout (Oncorhynchus mykiss) | ||
| Static test, 96 h |
a
Safety data sheet available at Sigma-Aldrich Web site.
b
According to EC Regulation No. 1272/2008 (CLP/GHS). The definition of the categories for each class of hazard are included in the text of the Regulation.
c
Amount of substance that kills 50% of test animals in a single dose.
d
Concentration at which 50% mortality occurs.
e
Oral LD50 to mice: 3.90 g/kg.