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Effects of drug treatment on host defense against C. albicans in HuCD4/Tg mice
| Treatment | Survival time (days after challenge [median]) | C. albicans-specific IgG level in serum (OD at 1/20 [mean ± SD]) |
|---|---|---|
| Vehicle | 5.0 | 0.53 ± 0.18 |
| Keliximab (1 mg/kg) | 6.0 | 0.56 ± 0.20 |
| Keliximab (100 mg/kg) | 5.0 | 0.21 ± 0.14 |
| Dexamethasone | 1.0a | 0.07 ± 0.02a |
Statistically significant decrease in comparison to control (P < 0.05).
