Skip to main content
. Author manuscript; available in PMC: 2022 Dec 29.
Published in final edited form as: Nat Neurosci. 2021 Nov 29;24(12):1648–1659. doi: 10.1038/s41593-021-00967-6

Fig. 1 ∣. Evidence of parvalbumin-expressing cell hypofunction in autism.

Fig. 1 ∣

There are several lines of converging evidence from human and animal studies that support a role of PV IN hypofunction in the pathogenesis of autism: (1) the density of PV INs is reduced; (2) the expression levels of PV protein are lower; (3) the density of PNNs around INs is decreased; (4) the power of baseline gamma oscillations (regulated by PV and SST INs) is increased; and (5) the activity of PV INs is decreased (for example, decreased visually evoked activity). FPKM, fragments per kilobase of transcript per million mapped reads.