Table 1.
Demographic and clinical characteristics of the recruited participants
| Variables | Discovery cohort | P* | Validation cohort | P* | P† | ||
|---|---|---|---|---|---|---|---|
| ATB (n = 468) | LTBI (n = 424) | ATB (n = 125) | LTBI (n = 138) | ||||
| Age, years | 52.38 ± 14.04 | 53.08 ± 14.47 | 0.573 | 51.70 ± 13.68 | 53.51 ± 13.59 | 0.209 | 0.785 |
| Sex, male, % | 289 (61.75%) | 247 (58.25%) | 0.287 | 81 (64.80%) | 83 (60.14%) | 0.436 | 0.508 |
| Underlying condition or illness | |||||||
| Diabetes mellitus | 92 (19.66%) | 77 (18.16%) | 0.569 | 27 (21.60%) | 24 (17.39%) | 0.389 | 0.872 |
| Virus hepatitis or cirrhosis | 52 (11.11%) | 39 (9.20%) | 0.346 | 16 (12.80%) | 16 (11.59%) | 0.765 | 0.364 |
| Nephritis or renal failure | 36 (7.69%) | 22 (5.19%) | 0.13 | 8 (6.40%) | 11 (7.97%) | 0.623 | 0.68 |
| Solid tumor | 30 (6.41%) | 27 (6.37%) | 0.979 | 7 (5.60%) | 9 (6.52%) | 0.755 | 0.858 |
| Heart disease | 29 (6.20%) | 18 (4.25%) | 0.193 | 6 (4.80%) | 6 (4.35%) | 0.861 | 0.648 |
| Positive culture for Mtb | 398 (85.04%) | N/A | N/A | 112 (89.60%) | N/A | N/A | N/A |
| Positive GeneXpert MTB/RIF | 381 (81.41%) | N/A | N/A | 106 (84.80%) | N/A | N/A | N/A |
ATB: active tuberculosis; LTBI: latent tuberculosis infection; Mtb: Mycobacterium tuberculosis; N/A: not applicable. *Comparisons were performed between ATB and LTBI groups using Mann–Whitney U test or Chi-square test. †Comparisons were performed between discovery cohort and validation cohort using Mann–Whitney U test or Chi-square test. Data were presented as means ± standard deviation or numbers (percentages)