Table 2.
Clinical outcomes according to liver fibrosis status
| Liver fibrosis staged by LFS | MACCE | All-cause death | Cardiac death | Myocardial infarction | Ischemic stroke | Major bleeding | TVR | Stent thrombosis |
|---|---|---|---|---|---|---|---|---|
| APRI | ||||||||
| Low (N = 5639) | 219 (3.9) | 77 (1.4) | 37 (0.7) | 72 (1.3) | 89 (1.6) | 169 (3.0) | 289 (5.1) | 53 (0.9) |
| Intermediate (N = 656) | 28 (4.3) | 10 (1.5) | 7 (1.1) | 14 (2.1) | 11 (1.7) | 18 (2.7) | 38 (5.8) | 8 (1.2) |
| High (n = 91) | 12 (13.2) | 6 (6.6) | 6 (6.6) | 4 (4.4) | 4 (4.4) | 3 (3.3) | 5 (5.5) | 5 (5.5) |
| p value | < 0.001 | < 0.001 | < 0.001 | 0.011 | 0.108 | 0.922 | 0.76 | < 0.001 |
| AST/ALT ratio | ||||||||
| Low (N = 3352) | 112 (3.3) | 31 (0.9) | 18 (0.5) | 37 (1.1) | 54 (1.6) | 94 (2.8) | 182 (5.4) | 30 (0.9) |
| Intermediate (N = 2666) | 116 (4.4) | 48 (1.8) | 23 (0.9) | 41 (1.5) | 43 (1.6) | 87 (3.3) | 123 (4.6) | 27 (1.0) |
| High (N = 368) | 31 (8.4) | 14 (3.8) | 9 (2.4) | 12 (3.3) | 7 (1.9) | 9 (2.4) | 27 (7.3) | 9 (2.4) |
| p value | < 0.001 | < 0.001 | < 0.001 | 0.003 | 0.913 | 0.481 | 0.06 | 0.02 |
| Forns score | ||||||||
| Low (N = 763) | 20 (2.6) | 5 (0.7) | 2 (0.3) | 8 (1.0) | 8 (1.0) | 17 (2.2) | 44 (5.8) | 5 (0.7) |
| Intermediate (N = 4582) | 188 (4.1) | 58 (1.3) | 32 (0.7) | 66 (1.4) | 83 (1.8) | 135 (2.9) | 242 (5.3) | 45 (1.0) |
| High (N = 1041) | 51 (4.9) | 30 (2.9) | 16 (1.5) | 16 (1.5) | 13 (1.2) | 38 (3.7) | 46 (4.4) | 16 (1.5) |
| p value | 0.051 | < 0.001 | 0.005 | 0.648 | 0.174 | 0.209 | 0.397 | 0.152 |
| NFS | ||||||||
| Low (N = 3109) | 92 (3.0) | 33 (1.1) | 17 (0.5) | 33 (1.1) | 37 (1.2) | 86 (2.8) | 157 (5.0) | 24 (0.8) |
| Intermediate (N = 2842) | 124 (4.4) | 41 (1.4) | 20 (0.7) | 43 (1.5) | 53 (1.9) | 89 (3.1) | 150 (5.3) | 28 (1.0) |
| High (N = 435) | 43 (9.9) | 19 (4.4) | 13 (3.0) | 14 (3.2) | 14 (3.2) | 15 (3.4) | 25 (5.7) | 14 (3.2) |
| p value | < 0.001 | < 0.001 | < 0.001 | 0.001 | 0.003 | 0.592 | 0.802 | < 0.001 |
LFS, liver fibrosis scores; MACCE, major adverse cardiac and cerebrovascular events; TVR, target vessel reconstruction; APRI, aspartate aminotransferase to platelet ratio index; AST/ALT ratio, aspartate aminotransferase to alanine aminotransferase ratio; NFS, nonalcoholic fatty liver disease fibrosis score