Table 3.
Linear mixed effects output for longitudinal data
| Global cognition | Episodic memory | Semantic memory | Perceptual speed | Visuospatial abilities | Working memory | |
|---|---|---|---|---|---|---|
| Age at baseline | β = − 0.26 | β = − 0.25 | β = − 0.23 | β = − 0.32 | β = − 0.09 | β = − 0.06 |
| SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | |
| t = − 19.58 | t = − 19.31 | t = − 16.96 | t = − 22.48 | t = − 6.78 | t = − 4.08 | |
| p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | |
| Education | β = 0.34 | β = 0.24 | β = 0.24 | β = 0.29 | β = 0.29 | β = 0.31 |
| SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | |
| t = 25.40 | t = 17.98 | t = 17.26 | t = 20.43 | t = 21.32 | t = 21.52 | |
| p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | |
| SCD classification | β = − 0.24 | β = − 0.27 | β = − 0.23 | β = − 0.17 | β = − 0.09 | β = − 0.06 |
| SE = 0.04 | SE = 0.03 | SE = 0.04 | SE = 0.04 | SE = 0.03 | SE = 0.04 | |
| t = − 6.71 | t = − 7.88 | t = − 6.43 | t = − 4.48 | t = − 2.28 | t = − 1.61 | |
| p < .001 | p < .001 | p < .001 | p < .001 | p = .022 | p = .11 | |
| Male sex | β = − 0.18 | β = − 0.26 | β = − 0.12 | β = − 0.24 | β = 0.32 | β = − 0.05 |
| SE = 0.04 | SE = 0.04 | SE = 0.04 | SE = 0.04 | SE = 0.04 | SE = 0.04 | |
| t = − 4.69 | t = − 7.09 | t = − 3.05 | t = − 5.88 | t = 8.33 | t = − 1.18 | |
| p < .001 | p < .001 | p = .002 | p < .001 | p < .001 | p = .24 | |
| TimeFromBaseline | β = − 0.19 | β = − 0.12 | β = − 0.20 | β = − 0.28 | β = − 0.08 | β = − 0.10 |
| SE < 0.01 | SE < 0.01 | SE < 0.01 | SE < 0.01 | SE < 0.01 | SE < 0.01 | |
| t = − 35.14 | t = − 19.02 | t = − 34.50 | t = − 53.54 | t = − 11.60 | t = − 17.43 | |
| p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | |
| Male sex: SCD classification | β = 0.09 | β = 0.14 | β = 0.06 | β = 0.01 | β = 0.15 | β = − 0.02 |
| SE = 0.07 | SE = 0.07 | SE = 0.07 | SE = 0.07 | SE = 0.08 | SE = 0.08 | |
| t = 1.27 | t = 1.96 | t = 0.75 | t = 0.17 | t = 2.10 | t = − 0.22 | |
| p = .20 | p = .05 | p = .45 | p = .86 | p = .036 | p = .83 | |
| SCD: TimeFromBaseline (females) | β = − 0.14 | β = − 0.15 | β = − 0.13 | β = − 0.07 | β = − 0.09 | β = − 0.08 |
| SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | SE = 0.01 | |
| t = − 12.85 | t = − 11.88 | t = − 11.49 | t = − 7.07 | t = − 7.02 | t = − 7.20 | |
| p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | p < .001 | |
| Male sex: TimeFromBaseline | β = − 0.02 | β < 0.01 | β = − 0.02 | β < − 0.01 | β = − 0.01 | β = − 0.04 |
| SE < 0.01 | SE < 0.01 | SE = 0.01 | SE < 0.01 | SE = 0.01 | SE = 0.01 | |
| t = − 1.73 | t = 0.25 | t = − 1.78 | t = − 0.37 | t = − 1.02 | t = − 3.72 | |
| p = .08 | p = .80 | p = .07 | p = .71 | p = .30 | p < .001 | |
| MaleSex: SCD classification: TimeFromBaseline | β = 0.10 | β = 0.09 | β = 0.07 | β = 0.06 | β = 0.10 | β = 0.06 |
| SE = 0.02 | SE = 0.02 | SE = 0.02 | SE = 0.02 | SE = 0.03 | SE = 0.02 | |
| t = 4.65 | t = 3.56 | t = 3.22 | t = 2.96 | t = 4.00 | t = 2.84 | |
| p < .001 | p < .001 | p = .001 | p = .003 | p < .001 | p = .004 | |
| Contrasts | ||||||
| SCD classification: TimeFromBaseline (males) | β = − 0.04 | β = − 0.06 | β = − 0.06 | β = − 0.01 | β < 0.01 | β = − 0.02 |
| SE = 0.02 | SE = 0.02 | SE = 0.02 | SE = 0.02 | SE = 0.02 | SE = 0.02 | |
| t = − 2.25 | t = − 2.97 | t = − 3.12 | t = − 0.87 | t = 0.4 | t = − 1.00 | |
| p = .024 | p = .003 | p = .001 | p = .38 | p = .68 | p = .32 | |
Bolded values are results that remained significant after FDR correction. The additional contrast was completed to examine the difference in rate of change for male SCD + vs. male SCD −