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Models of ERα–RNA binding. Top: Recruitment model wherein ERα binds nascently transcribed RNA or other transcripts in cis, guiding it to the ERE promoter. Chromatin occupancy increases and transcription is upregulated. Bottom: Repression model wherein ERα bound to non-ERE promoter can be sequestered away by binding a lncRNA with multiple binding sites, decreasing promoter occupancy, and downregulating transcription. Nucleic acid binding domain (NBD) shown in gray, estrogen bound (E2).
