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. 2022 Dec 29;21:76. doi: 10.1186/s12937-022-00832-7

Table 3.

Relationship between HFCS sweetened drink, diet soft drinks intake and serum sodium in different models

Intake, servings/day Model I Model II Model III Model IV
β (95%CI)a p-value β (95%CI)a p-value β (95%CI)a p-value β (95%CI)a p-value
HFCS Sweetened drinks (n = 5396) (n = 2547) (n = 2547) (n = 2547)
 Per 1 serving increment 0.05 (− 0.02,0.11) 0.185 0.06 (−0.06,0.18) 0.281 0.05 (0.00,0.11) 0.044 0.05 (0.00,0.11) 0.049
 Quantiles
  Q1 Reference Reference Reference Reference
  Q2 0.32 (0.17,0.58) 0.003 0.39 (0.06,0.74) 0.026 0.16 (0.00,0.33) 0.051 0.16 (−0.02,0.34) 0.065
  Q3 0.22 (− 0.02,0.42) 0.070 0.19 (− 0.16,0.53) 0.255 0.19 (0.02,0.37) 0.038 0.19 (0.00,0.38) 0.049
  Q4 0.32 (0.09,0.53) 0.009 0.34 (−0.08,0.72) 0.093 0.21 (0.07,0.36) 0.014 0.21 (0.05,0.37) 0.020
P for trend 0.105 0.139 0.047 0.051
Diet soft drinks (n = 2371) (n = 1535) (n = 1535) (n = 1535)
 Per 1 serving increment 0.06 (−0.02,0.14) 0.138 0.06 (−0.05,0.18) 0.279 0.00 (−0.04,0.04) 0.956 0.00 (−0.04,0.05) 0.967
 Quantiles
  Q1 Reference Reference Reference Reference
  Q2 0.08 (−0.19,0.35) 0.561 0.10 (−0.21,0.42) 0.492 0.06 (−0.12,0.23) 0.459 0.05 (−0.14,0.24) 0.513
  Q3 0.11 (−0.18,0.40) 0.467 0.27 (−0.08,0.63) 0.118 0.06 (−0.10,0.22) 0.410 0.05(−0.12,0.23) 0.448
  Q4 0.23 (−0.04,0.50) 0.116 0.26 (−0.15,0.67) 0.191 0.06 (−0.14,0.25) 0.498 0.05 (−0.15,0.26) 0.530
P for trend 0.093 0.321 0.759 0.760

Model I adjusted for age, sex and race

Model II adjusted for Model I + education, poverty income ratio, physical activity, total energy, history of hypertension

Model III adjusted for Model II + BMI, diuretics use, serum potassium, serum chloride, osmolality, eGFR, and intake of dietary sodium, total moisture

Model IV adjusted for Model III + serum uric acid

Abbreviations: CI Confidence interval, HFCS High fructose corn syrup

aValues are β coefficients (95% CIs)