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. 2022 Dec 13;16(12):20163–20173. doi: 10.1021/acsnano.2c04829

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© 2022 The Authors. Published by American Chemical Society

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(A) Intensity profiles of three representative LNPs displaying sudden intensity increase after binding to the ncSLB (the insets show the corresponding TIRF micrographs (8.0 × 7.0 μm²) prior to and after the intensity increase. (B) Intensity histograms for all LNPs (blue) adsorbed to the ncSLB for pristine LNPs in comparison with LNPs preincubated in 10% Lipo-D and 10% FBS measured at the end of each experiment (∼1100 s). The yellow bars represent the fraction of LNPs that displayed one or more sudden intensity increases.