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. 2022 Nov 25;378(6622):eabo2523. doi: 10.1126/science.abo2523

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Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).

This is an open-access article distributed under the terms of the Creative Commons Attribution license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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A parenteral prime-unadjuvanted mucosal boost vaccine that elicits mucosal immunity against sarbecoviruses. — P&S converts systemic immunity generated by primary vaccination into local immunity in the respiratory mucosa. P&S affords protection against disease development, respiratory viral replication, and contact transmission after SARS-CoV-2 (SCV2) infection. Intranasal boosting by using a divergent spike protein from SARS-CoV-1 (SCV1) induces mucosal immunity against diverse sarbecovirus clades.

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