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. 2022 Nov 21;324(1):G60–G77. doi: 10.1152/ajpgi.00112.2022

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Published by the American Physiological Society.

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Figure 5. — Apical sodium bile acid (BA) transporter (ASBT) inhibition alters hepatic and ileal BA transporter expression. Hepatocyte mRNA expression of BA transporters multidrug resistance-associated protein 3 (MRP3, A) and bile salt export pump (BSEP, B) significantly increased, while NTCP (C) significantly decreased, in multidrug-resistant 2 knockout (Mdr2^−/−) Control mice compared with wild-type (WT) mice. ASBT Vivo-Morpholino (VM) treatment decreased MRP3 (A) and BSEP (B) while increasing NTCP (C) expression in Mdr2^−/− mice compared with Control. ASBT VM treatment increased OATP (Slco1b1) (D), OSTβ (Slc51b) (E), OSTα (Slc5a1) (F), and MRP2 (Abcc2) (G) in WT mice compared with Control; however, OATP (D) and OSTβ (E) were increased, OSTα (F) unchanged, and MRP2 (G) decreased in Mdr2^−/− after ASBT VM treatment compared with Control. Data are presented as mean ± SD of 4 experiments for qPCR from 7 to 10 mice per group. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.