Table 2.
Clinical and Laboratory Measures in the Losartan Treatment Group
| Physical measurements (losartan treatment group) | % Change, baseline to Visit 4 | 95% CI p-value |
Losartan | 95% CI p-value |
EXP3174 | 95% CI p-value |
EXP3179 | 95% CI p-value |
|---|---|---|---|---|---|---|---|---|
| Systolic blood pressure (mmHg) | ↓ 10% | 0.84, 0.96 .002 |
― | ― | ― | ― | ― | ― |
| Diastolic blood pressure (mmHg) | ↓ 7% | 0.87, 1.00 .046 |
0.04 | 0.02, 0.06 <.001 |
2.3 | 0.6, 4.1 .008 |
||
| Heart rate (beats per minute) | ↑ 11% | 1.02, 1.20 .01 |
― | ― | ― | ― | ― | ― |
| Blood urea nitrogen (mg/dL) | ↑ 15% | 1.09, 1.22 ≤.001 |
― | ― | ― | ― | ― | ― |
| Chloride (mEq/L) | ↑ 2% | 1.00, 1.03 .02 |
0.01 | 0.003, 0.02 .003 |
― | ― | ― | ― |
| CO2 (mmol/L) | ↓ 5% | 0.91, 0.99 .015 |
― | ― | ― | ― | ― | ― |
| Knee srength (N) | ― | ― | ― | ― | 0.01 | 0.002, 0.02 .007 |
3.2 | 1.7, 4.6 <.001 |
| Frailty score | ― | ― | −0.001 | −0.001, −0.003 .005 |
― | ― | −0.09 | −0.16, −0.01 .02 |
Note: Upward arrows indicate positive correlations, downward arrows indicate negative correlations, and dashes indicate no correlation.