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. Author manuscript; available in PMC: 2022 Dec 29.
Published in final edited form as: Cell Rep. 2022 Sep 13;40(11):111334. doi: 10.1016/j.celrep.2022.111334

Figure 1. TrkB is necessary for outcome-specific value memory updating, but not retrieval.

Figure 1.

(A) Schematic: Mice were trained to respond for 2 food pellets. Then, the value of 1 pellet was reduced via CTA. Whether mice updated their behavior was then measured in a choice test. Syringes indicate drug treatment during value updating or retrieval epochs.

(B) Response acquisition.

(C) Food consumption during CTA.

(D) TrkB inhibition during outcome value updating, but not retrieval, obstructed the ability of mice to preferentially respond for valued outcomes.

(E) Nevertheless, all groups preferentially consumed the valued versus devalued outcome during the post-probe consumption test. Symbols and shading, means ± SEMs; bars and lines connecting bars, means + individual data points; *p < 0.05, **p < 0.001. n.s., non-significant. n = 16 vehicle updating, n = 12 ANA-12 updating, n = 8 vehicle retrieval, n = 8 ANA-12 retrieval.