Figure 2.

Identification of SARS‐CoV‐2 epitopes and computational designs of epitope‐scaffold proteins. a) Three epitopes from the S2 domain of spike were selected based on sequence conservation and surface exposure. Three epitopes are shown in red, gold, and purple color. b) Computational models of epitope‐scaffolds. Five stable, computationally designed epitope‐scaffolds were expressed in E. coli. Scaffold proteins are shown in green. Grafted regions are shown in red, gold and purple.