Table 5.

Current Procedural Terminology (CPT) Codes for Pharmacogenomic Testing for Common Gene-Drug Pairs

Gene/Test	CPT Code	Intended use for Drug
CYP2C19	81225	Clopidogrel, voriconazole, proton pump inhibitors, selected selective serotonin reuptake inhibitors (SSRIs)
CYP2C9	81227	Phenytoin, warfarin, selected non-steroidal anti-inflammatory drugs
CYP4F2	81479	Warfarin
VKORC1	81355	Warfarin
CYP2D6	81226, 0070U, 0071U, 0072U, 0073U, 0074U, 0075U, 0076U	Atomoxetine, codeine, ondansetron, tropisetron, tamoxifen, selected SSRIs and tricyclic antidepressants
DPYD	81232	Fluoropyrimidines
G6PD	81247	Rasburicase
SLCO1B1	81328	Simvastatin
NUDT15	81306	Thiopurines
TPMT	81335	Thiopurines
UGT1A1	81350	Atazanavir

^*The complete list of CPT codes for pharmacogenomic testing is available at www.cms.gov.

Cytochrome P450 (CYP)

Vitamin K Epoxide Reductase Complex (VKORC)

Dihydropyrimidine dehydrogenase (DPYD)

glucose-6-phosphate-dehydrogenase (G6PD)

Solute carrier organic anion transporter (SLCO)

Nudix hydrolase (NUDT)

Thiopurine methyltransferase (TPMT)

UDP-glucuronosyltransferase (UGT)