Fig 7. Within-population interferences between BDMi mutations slow down their fixation, and occur less in highly selfing populations (two-locus model).

The A panel shows the fixation time of co-dominant BDMi mutations (h_b = 0.5), and with a strength of selection (s_b) of either 0 (blue), 2.5.10⁻⁴ (yellow), or 2.5.10⁻³ (red). The B panel shows the fixation time of BDMi mutations with a strength of selection (s_b) of 2.5.10⁻⁴ that are either recessive (h_b = 0.1; light blue), co-dominant (h_b = 0.5; green), or dominant (h_b = 0.9; light green). The solid lines in the neutral scenario correspond to analytical approximations: 1/2μ (light grey), and Eq (17) (dark grey) (see BDMi Results section for details on the approximations). Each phase portrait shows, for a single simulation, the change in allele frequencies of A₂ and B₂ plotted from the beginning, and then every 100 generations until the fixation of a derived allele. The isoclines represent the expected benefits (warm colours) and costs (cold colours) on population fitness (multiplied by N_e, and with a increment of 1). The direction of the arrow indicates the expected allele change (which is the balance between mutation rates and selection), and their size indicates the strength of the change. N = 10, 000, k_b = h_b, s = 0, r = 0.5. 10, 000 iterations.