Table 3.
Association between care home resident characteristics and the prescription of oral anticoagulation for atrial fibrillationa
| Characteristics of residents with atrial fibrillation | Unadjusted odds ratio (95% CI) | Adjusted odds ratio (95% CI) | P-valueb |
|---|---|---|---|
| Demographics | |||
| Age, per 1-year increase | 0.96 (0.96 to 0.97) | 0.96 (0.95 to 0.96) | <0.001 |
| Age category | |||
| 65–74 years | Reference | ||
| 75–84 years | 0.96 (0.83 to 1.12) | ||
| 85–94 years | 0.71 (0.61 to 0.82) | ||
| ≥95 years | 0.35 (0.29 to 0.42) | ||
| Sex, male | 1.26 (1.18 to 1.35) | 1.09 (1.01 to 1.18) | 0.024 |
| WIMD quintile | |||
| 1 (most deprived) | Reference | ||
| 2 | 1.01 (0.91 to 1.13) | ||
| 3 | 1.00 (0.90 to 1.11) | ||
| 4 | 1.00 (0.90 to 1.11) | ||
|
| |||
| Year of care home entry ≥2011 | 2.27 (2.12 to 2.43) | 1.91 (1.76 to 2.06) | <0.001 |
|
| |||
| Frailty | |||
| No frailty | Reference | Reference | |
| Mild | 4.45 (3.85 to 5.14) | 4.61 (3.95 to 5.38) | <0.001 |
| Moderate | 7.33 (6.36 to 8.44) | 6.69 (5.74 to 7.80) | <0.001 |
| Severe | 10.68 (9.23 to 12.36) | 8.42 (7.16 to 9.90) | <0.001 |
|
| |||
| Social history before care home entry | |||
| Smoking history | 1.82 (1.69 to 1.96) | 1.16 (1.06 to 1.26) | 0.001 |
| Harmful alcohol usec | 1.51 (1.34 to 1.70) | 1.00 (0.88 to 1.14) | 0.966 |
|
| |||
| Medical history before care home entry | |||
| Dementiad | 0.91 (0.81 to 1.03) | ||
| Pulmonary diseasee | 1.38 (1.26 to 1.50) | 0.94 (0.85 to 1.03) | 0.191 |
| Peptic ulcer | 1.01 (0.84 to 1.23) | ||
| Cancer | 1.22 (1.11 to 1.33) | 1.04 (0.94 to 1.15) | 0.401 |
| Dyslipidaemia | 1.81 (1.63 to 2.00) | 1.13 (1.02 to 1.27) | 0.025 |
| Haemorrhagic stroke | 1.42 (1.14 to 1.76) | 1.18 (0.93 to 1.50) | 0.183 |
| Ischaemic stroke | 1.58 (1.44 to 1.73) | 1.51 (1.37 to 1.67) | <0.001 |
| Stroke of unknown origin | 1.42 (1.20 to 1.67) | 1.32 (1.10 to 1.58) | 0.002 |
| Transient ischaemic attack | 1.29 (1.12 to 1.49) | 1.22 (1.04 to 1.43) | 0.012 |
| Myocardial infarction | 1.08 (0.96 to 1.22) | ||
| Heart failure | 1.63 (1.51 to 1.75) | 1.46 (1.35 to 1.58) | <0.001 |
| Diabetes | 1.54 (1.33 to 1.80) | 1.05 (0.88 to 1.24) | 0.603 |
| Renal disease | 1.41 (1.24 to 1.60) | 0.96 (0.84 to 1.11) | 0.582 |
| Liver disease | 0.84 (0.47 to 1.52) | ||
| Hypertension | 1.65 (1.54 to 1.76) | 1.05 (0.98 to 1.13) | 0.176 |
| Peripheral vascular disease | 1.54 (1.34 to 1.78) | 1.09 (0.93 to 1.26) | 0.293 |
| Aortic plaque | 1.76 (0.42 to 7.35) | ||
| Major bleeding | 1.62 (1.48 to 1.76) | 1.35 (1.23 to 1.48) | <0.001 |
| Venous thromboembolism | 4.38 (3.48 to 5.51) | 4.06 (3.17 to 5.20) | <0.001 |
|
| |||
| Medication history within 6 months before care home entry | |||
| Prescription of antiplatelet(s) without NSAID(s) | 0.88 (0.83 to 0.95) | 0.91 (0.84 to 0.98) | 0.014 |
| Prescription of NSAID(s) without antiplatelet(s) | 2.05 (1.80 to 2.33) | 1.75 (1.51 to 2.02) | <0.001 |
a
Prescription within 6 months before care home entry used as a proxy for prescription at the point of care home entry.
b
Reported for adjusted odds ratio.
c
Including alcoholism and heavy drinker.
d
Including Alzheimer’s disease, vascular dementia, younger-onset dementia, and other or unspecified dementia.
e
Including asthma, chronic obstructive pulmonary disease, and other pulmonary. NSAID = non-steroidal anti-inflammatory drug. WIMD = Welsh Index of Multiple Deprivation.