Table 1.
Sociodemographic characteristics and medical history of primary care patients aged ≥45 years overall, and with a BNP or NT-pro BNP test
| Characteristic | BNP test (n = 74 233) | NT-pro BNP test (n = 155 347) | Overall (N = 229 580) |
|---|---|---|---|
| Age, years, median (IQR) | 62.0 (53.0–70.0) | 61.0 (52.0–69.0) | 61.2 (52.0–69.1) |
|
| |||
| Sex, female, n (%) | 42 538 (57.3) | 89 464 (57.6) | 132 002 (57.5) |
|
| |||
| Ethnicity, n (%) | |||
| White | 68 280 (92.0) | 141 661 (91.2) | 209 941 (91.4) |
| Indian | 1195 (1.61) | 2318 (1.49) | 3513 (1.53) |
| Pakistani | 608 (0.82) | 1201 (0.77) | 1809 (0.79) |
| Bangladeshi | 102 (0.14) | 352 (0.23) | 454 (0.20) |
| Chinese | 121 (0.16) | 266 (0.17) | 387 (0.17) |
| Other Asian | 692 (0.93) | 1094 (0.70) | 1786 (0.78) |
| Black Caribbean | 455 (0.61) | 1756 (1.13) | 2211 (0.96) |
| Black African | 354 (0.48) | 1251 (0.81) | 1605 (0.70) |
| Other Black | 148 (0.20) | 706 (0.45) | 854 (0.37) |
| Mixed | 292 (0.39) | 577 (0.37) | 869 (0.38) |
| Other | 596 (0.80) | 1425 (0.92) | 2201 (0.88) |
| Missing | 1390 (1.87) | 2740 (1.76) | 4130 (1.80) |
|
| |||
| BMI, kg/m2, median (IQR) | 28.4 (24.9–32.7) | 28.7 (25.1–32.9) | 28.6 (25.1–32.9) |
|
| |||
| Smoking status, n (%) | |||
| Never | 25 303 (34.1) | 50 629 (32.6) | 75 932 (33.1) |
| Former | 37 807 (50.9) | 79 714 (51.3) | 117 521 (51.2) |
| Current | 10 985 (14.8) | 24 691 (15.9) | 35 676 (15.5) |
| Missing | 138 (0.19) | 313 (0.20) | 451 (0.20) |
|
| |||
| IMD, quintile, n (%) | |||
| Q1 (least deprived) | 21 096 (28.4) | 30 085 (19.4) | 51 181 (22.3) |
| Q2 | 16 822 (22.7) | 32 861 (21.2) | 49 683 (21.6) |
| Q3 | 15 665 (21.1) | 31 593 (20.3) | 47 258 (20.6) |
| Q4 | 13 374 (18.0) | 31 187 (20.1) | 44 561 (19.4) |
| Q5 (most deprived) | 7260 (9.8) | 29 527 (19.0) | 36 787 (16.0) |
| Missing | 16 (0.02) | 94 (0.06) | 110 (0.05) |
|
| |||
| Medical history, n (%) | |||
| Diabetes | 16 896 (22.8) | 39 886 (25.7) | 56 782 (24.7) |
| Hypertension | 44 166 (59.5) | 91 622 (59.0) | 135 788 (59.1) |
| Atrial fibrillation | 8822 (11.9) | 17 403 (11.2) | 26 225 (11.4) |
| Angina | 6648 (8.96) | 14 442 (9.30) | 21 090 (9.19) |
| Ischaemic heart disease | 8705 (11.7) | 18 007 (11.6) | 26 712 (11.6) |
| Myocardial infarction | 4745 (6.39) | 9729 (6.26) | 14 474 (6.30) |
| Stroke | 5678 (7.65) | 12 629 (8.13) | 18 307 (7.97) |
| Valvular disease | 2949 (3.97) | 5689 (3.66) | 8638 (3.76) |
| Other CVD | 10 586 (14.3) | 21 438 (13.8) | 32 024 (13.9) |
|
| |||
| SBP, mmHg, median (IQR) | 136 (126–145) | 136 (126–145) | 136 (126–145) |
|
| |||
| DBP, mmHg, median (IQR) | 78 (70–83) | 78 (70–83) | 78 (70–83) |
|
| |||
| Total cholesterol, mmol/L, median (IQR) | 4.8 (4.0–5.6) | 4.8 (4.0–5.6) | 4.8 (4.0–5.6) |
|
| |||
| BNP, pg/mL, median (IQR) | 61.1 (26.4–155.0) | — | 61.1 (26.4–155.0) |
|
| |||
| NT-proBNP, pg/mL, median (IQR) | — | 143.0 (60.0–413.0) | 143.0 (60.0–413.0) |
|
| |||
| Time between NP test and HF diagnosis | |||
| Days, median (IQR) | 26 (8–66) | 26 (7–64) | 26 (7–65) |
| <2 weeks, n (%) | 2313 (36.7) | 5359 (35.5) | 7672 (36.4) |
| 2–6 weeks, n (%) | 1634 (25.4) | 3699 (25.1) | 5333 (25.3) |
| ≥6 weeks,n (%) | 2570 (37.9) | 5527 (39.4) | 8097 (38.4) |
BMI = body mass index. BNP = B-type natriuretic peptide. CVD = cardiovascular disease. DBP = diastolic blood pressure. HF = heart failure. IMD = Index of Multiple Deprivation. IQR = interquartile range (25th and 75th percentiles). NP = natriuretic peptide. Q = quintile. SBP = systolic blood pressure.