Table 3.
Diagnostic test accuracy parameters for the diagnosis of HF using BNP and NT-proBNP level NICE and ESC referral thresholdsa
| Test | BNP (total N= 74 233, HF n = 6517, 8.8%) | NT-proBNP (total N= 155 347, HF n= 14 585, 9.4%) | ||||
|---|---|---|---|---|---|---|
| Cut off, ≥35 pg/mL | Cut off, ≥100 pg/mL | Cut off, >400 pg/mL | Cut off, ≥125 pg/mL | Cut off, ≥400 pg/mL | Cut off, >2000 pg/mL | |
| TP, n | 6313 | 5769 | 2909 | 13 801 | 11 913 | 5674 |
| FN, n | 204 | 748 | 3608 | 784 | 2672 | 8911 |
| FP, n | 43 793 | 20 942 | 4510 | 70 365 | 27 788 | 5424 |
| TN, n | 23 923 | 46 774 | 63 206 | 70 397 | 112 974 | 135 338 |
| Sensitivity, % (95% CI) | 96.9 (96.4 to 97.3) | 88.5 (87.7 to 89.3) | 44.6 (43.4 to 45.9) | 94.6 (94.2 to 95.0) | 81.7 (81.0 to 82.3) | 38.9 (38.1 to 39.7) |
| Specificity, % (95% CI) | 35.3 (35.0 to 35.7) | 69.1 (68.7 to 69.4) | 93.3 (93.1 to 93.5) | 50.0 (49.7 to 50.3) | 80.3 (80.0 to 80.5) | 96.1 (96.0 to 96.2) |
| PPV, % (95% CI) | 12.6 (12.3 to 12.9) | 21.6 (21.1 to 22.1) | 39.2 (38.1 to 40.3) | 16.4 (16.1 to 16.6) | 30.0 (29.6 to 30.5) | 51.1 (50.2 to 52.1) |
| NPV, % (95% CI) | 99.2 (99.0 to 99.3) | 98.4 (98.3 to 98.5) | 94.6 (94.4 to 94.8) | 98.9 (98.8 to 99.0) | 97.7 (97.6 to 97.8) | 93.8 (93.7 to 93.9) |
| LR+ (95% CI) | 1.50 (1.49 to 1.51) | 2.86 (2.82 to 2.90) | 6.70 (6.45 to 6.97) | 1.89 (1.88 to 1.91) | 4.14 (4.08 to 4.19) | 10.1 (9.77 to 10.44) |
| LR– (95% CI) | 0.09 (0.08 to 0.10) | 0.17 (0.16 to 0.18) | 0.59 (0.58 to 0.61) | 0.11 (0.10 to 0.12) | 0.23 (0.22 to 0.24) | 0.64 (0.63 to 0.64) |
| DOR (95% CI) | 16.89 (14.72 to 19.5) | 17.22 (15.94 to 18.63) | 11.30 (10.67 to 11.97) | 17.61 (16.38 to 18.94) | 18.12 (17.35 to 18.93) | 15.89 (15.22 to 16.59) |
a
The overall number of participants (total N) with either test was different, therefore also the number with HF, as well as the prevalence (%). BNP = B-type NP. DOR = diagnostic odds ratio. ESC = European Society of Cardiology. FN = false negative. FP = false positive. HF = heart failure. LR = likelihood ratio. NICE = National Institute for Health and Care Excellence. NP = natriuretic peptide. NPV = negative predictive value. PPV = positive predictive value. TN = true negative. TP = true positive.