FIG. 6.
Effect of auxotrophy on survival and multiplication in the tissues of DBA/2 mice. Mice were infected with 106 H37Rv (●) or mutant strain metB (○), proC (▾), or trpD (▿). CFU were assayed at various intervals on 7H10 agar with or without appropriate amino acid supplementation. The results represent means ± standard errors for three mice per group. Significance was measured using Student's t test. The dotted line represents the reliable limit of detection. The results are representative of two separate experiments.