TABLE 2.

Up-regulation of MHC class II molecules induced by aluminum hydroxide is abolished in the presence of neutralizing IL-4 antibody^a

Molecule	Mean fluorescence intensity
	Medium	Aluminum hydroxide	Aluminum hydroxide + anti-IL-4
MHC class II	2,655.3 (627.4–2,883.0)	3,490.0 (1,848.2–3,579.5)	1,965.4 (663.8–2,734.0)
HLA-DR	2,530.4 (1,010.9–4,050.0)	3,465.3 (2,278.7–4,652.0)	2,453.5 (1,046.1–3,861.0)
HLA-DP	3,047.0 (763.5–3,248.7)	3,655.0 (2,258.0–4,420.8)b	2,529.3 (930.4–3,046.0)
HLA-DQ	336.3 (140.6–532.0)	372.2 (246.5–498.0)	261.3 (124.6–398.0)

^aIsolated PBMC were cultured for 48 h with medium alone. Al(OH)₃, plus anti-IL-4. The experiment was performed as described for Fig. 2. The mean fluorescence intensity of cells stained with FITC- or PE-conjugated MAbs within a gate of big granular cells was determined. Data are median values (minimum and maximum values are in parentheses) of four independent experiments. 

^bSignificantly different (P < 0.05) from the value for PBMC cultured with medium only, as calculated by the paired Wilcoxon signed-rank test.