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. 2022 Dec 29;12:22570. doi: 10.1038/s41598-022-26943-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Isolated MDSCs induced CD4 + CD25- Foxp3 + T cells. Isolated MDSCs from fresh PBMC of patients co-cultured with autologous MDPs from the same patients and homologous PBMCs from HCs in the presence of PHA for 3 days. Dot plots show the percentage of CD4⁺CD25⁺Foxp3⁺ (A), CD4⁺CD25^-Foxp3⁺ (B) and CD4⁺Foxp3⁺ cells (C) from 18 COVID-19 patients and 9 HCs All values are presented as the median and 5–95% percentile and comparisons made between control and patient groups were performed using kruskalwalis followed a Dunn's test. *P < 0.01, **P < 0.001, ***P < 0.0001 and ****P < 0.0001. HC healthy control, P: patients, MDP MDSC depleted PBMC.