Figure 2.

pSS mice treated with Imq exhibit robust lymphocytic infiltration of exocrine tissues and loss of salivary flow. (A) SMG and (B) lacrimal tissues were harvested from sham (n = 10) or Imq-treated female mice (n = 9) and from sham (n = 6) or Imq-treated age and sex-matched controls (n = 6). One representative photomicrograph is shown from each group. White arrows indicate exocrine gland ducts and black arrows indicate inflammation. Lymphocytic infiltration was quantified using ImageJ. Horizontal lines represent the mean and SEM (C) Stimulated saliva was collected prior to treatment and at the conclusion of the experiment from BL/10 and NOD.B10 mice. (NS = non-significant, *p < 0.05, **p < 0.001, ***p < 0.001).