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. 2022 Dec 15;13:1034336. doi: 10.3389/fimmu.2022.1034336

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Copyright © 2022 Punnanitinont, Kasperek, Kiripolsky, Zhu, Miecznikowski and Kramer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TLR7 agonism induces significant pulmonary and renal inflammation in pSS mice. (A) Lung and (B) kidney tissues were harvested from sham (n = 10) or Imq-treated female pSS mice (n = 9) and from sham (n = 6) or Imq-treated age and sex-matched controls (n = 6). One representative photomicrograph is shown from each group. Lymphocytic infiltration was quantified using ImageJ and black arrows indicate tissue inflammation. Horizontal lines represent the mean and SEM (NS = non-significant, *p < 0.05).