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. 2022 Dec 15;13:1034336. doi: 10.3389/fimmu.2022.1034336

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Copyright © 2022 Punnanitinont, Kasperek, Kiripolsky, Zhu, Miecznikowski and Kramer

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Autoantigen arrays reveal enrichment of autoantibodies in the sera of Imq-treated NOD.B10 mice. Sera were harvested from NOD.B10 sham (n = 9) or Imq-treated female mice (n = 7) by cardiac puncture following euthanasia. Sera were harvested similarly from BL/10 sham (n = 6) or Imq-treated female BL/10 mice (n = 6). Autoantigen arrays were performed and heatmaps for ANA-specific (A) IgM and (C) IgG are shown. ANA-specific (B) IgM and (D) IgG that was significantly enriched in Imq-treated BL/10 and NOD.B10 mice as compared to sham-treated strain-matched controls is shown.