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Comparison of Disease Manifestations between Imq-treated NOD.B10 mice and clinical disease stage NOD.B10 females.
| Imq-induced | Clinical disease (spontaneous) | |
|---|---|---|
| Sialadenitis - SMG | Yes | Yes |
| Sialadenitis- Parotid | Negligible | Negligible |
| Hyposalivation | Yes | Yes |
| Dacryoadenitis | Yes | Yes |
| Nephritis | Yes | Yes |
| Pneumonitis | Yes | Yes |
| Elevated serum IgM | No | Yes |
| Elevated serum IgG | Yes | Yes |
| Autoantibodies | Yes | Yes |
| Splenomegaly | Yes | No |
| Cervical Lymphadenopathy | Yes | Minimal |
