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. 2022 Dec 15;13:1063129. doi: 10.3389/fimmu.2022.1063129

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Copyright © 2022 Xu, Li, Li, Guo, Lin, Lu, Hou, Govinden, Deng and Chenia

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic of AIV HA2 DNA vaccine delivered by dendritic cell (DC)-targeting phages. (A) Construction of eukaryotic expression plasmids containing the AIV HA2 gene and anchor sequence (AS). (B) DC-targeting phages encapsulate pEGFP-C1-HA2-AS plasmid during the reproduction process in Escherichia coli BL21. (C) DC-targeting phages deliver pEGFP-C1-HA2-AS plasmid into DCs and activate HA2 protein expression. (D) Immunogenicity evaluation of HA2 DNA vaccine in specified pathogen-free (SPF) chicken delivered by Lipofectin and DC-targeting phages.